ChemicalBook > CAS DataBase List > 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

Product Name: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE
CAS No.: 138227-63-1
Chemical Name: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE
Synonyms: Boc-4-(4-amino-phenoxy)piperidine;4-[(1-Boc-4-piperidyl)oxy]aniline;N-Boc-4-(4-aminophenoxy)piperidine;1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE;1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE;tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline;tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate;1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98%
CBNumber: CB3330113
Molecular Formula: C16H24N2O3
Formula Weight: 292.37
MOL File: 138227-63-1.mol

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1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Property

Boiling point:: 430.3±35.0 °C(Predicted)
Density: 1.140±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.11±0.10(Predicted)
Appearance: Brown to dark brown Solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809788
Product name: tert-Butyl4-(4-Aminophenoxy)piperidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J54765
Product name: 1-Boc-4-(4-aminophenoxy)piperidine
Packaging: 250mg
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51390
Product name: 1-Boc-4-(4-aminophenoxy)piperidine
Packaging: 250mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: W3012
Product name: 1-Boc-4-(4-aminophenoxy)piperidine
Packaging: 1g
Price: $114
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51390
Product name: 1-Boc-4-(4-aminophenoxy)piperidine
Packaging: 500mg
Price: $135
Updated: 2021/12/16

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1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

138227-62-0

138227-63-1

The general procedure for the synthesis of 1-Boc-4-(4-aminophenoxy)piperidine from tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate was as follows: 4-(1-tert-butoxycarbonylpiperidin-4-yloxy)nitrobenzene (11.9 g) obtained in Reference Example 105 was dissolved in methanol (100 mL) and palladium-carbon catalyst (1.9 g) was added. The reaction mixture was stirred at room temperature for 4 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate in the ratio of 1:1, v/v. The final product was 1-Boc-4-(4-aminophenoxy)piperidine (10.7 g, 99% yield) as a light red solid.1H NMR (400 MHz, CDCl3) δ ppm: 1.46 (9H, s), 1.71 (2H, m). 1.87 (2H, m), 3.27 (2H, m), 3.71 (2H, m), 4.26 (1H, m), 6.63 (2H, d, J = 8.5 Hz), 6.76 (2H, d, J = 8.5 Hz).

References

[1] Chemical and Pharmaceutical Bulletin, 2008, vol. 56, # 6, p. 758 - 770
[2] Patent: EP1375482, 2004, A1. Location in patent: Page 159
[3] Bioorganic and medicinal chemistry, 2002, vol. 10, # 5, p. 1509 - 1523
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 1 - 7
[5] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 205; 206

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Suppliers

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138227-63-1, 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINERelated Search:

1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE 6-ACETYLAMINO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 6-ACETYLAMINO-4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE 1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

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1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

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tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate

tert-Butyl 4-(4-aminophenoxy)tetrahydro-1(2H)-pyridinecarboxylate

4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline

tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(4-aMinophenoxy)-, 1,1-diMethylethyl ester

N-Boc-4-(4-aminophenoxy)piperidine

4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98%

4-(4-aminophenoxy)-1-piperidinecarboxylic acid tert-butyl ester

4-[(1-Boc-4-piperidyl)oxy]aniline

1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1

138227-63-1

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