CAIX Inhibitor S4

Product Name: CAIX Inhibitor S4
CAS No.: 1330061-67-0
Chemical Name: CAIX Inhibitor S4
Synonyms: S4 >=98% (HPLC);CAIX Inhibitor S4;CAIX Inhibitor S4, 10 mM in DMSO;4-(3-(3,5-Dimethylphenyl)ureido)phenyl sulfamate;4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate;Sulfamic acid, 4-[[[(3,5-dimethylphenyl)amino]carbonyl]amino]phenyl ester
CBNumber: CB33309354
Molecular Formula: C15H17N3O4S
Formula Weight: 335.38
MOL File: 1330061-67-0.mol

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CAIX Inhibitor S4 Property

Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 30 mg/ml
form: A solid
pka: 8.63±0.70(Predicted)
color: White to off-white
InChI: InChI=1S/C15H17N3O4S/c1-10-7-11(2)9-13(8-10)18-15(19)17-12-3-5-14(6-4-12)22-23(16,20)21/h3-9H,1-2H3,(H2,16,20,21)(H2,17,18,19)
InChIKey: HGVHSNXRZYOTPD-UHFFFAOYSA-N
SMILES: S(N)(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2031
Product name: S4
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $87.03
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2031
Product name: S4
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $371
Updated: 2025/07/31

TRC

Product number: S019995
Product name: S4
Packaging: 50mg
Price: $470
Updated: 2021/12/16

Axon Medchem

Product number: Axon2662
Product name: CAIXInhibitorS4
Purity: 99%
Packaging: 50mg
Price: $374
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009832
Product name: S-4
Purity: 95.00%
Packaging: 5MG
Price: $455.08
Updated: 2021/12/16

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CAIX Inhibitor S4 Chemical Properties,Usage,Production

Uses

S4 is a sulfamate carbonic anhydrase IX (CAIX) inhibitor in colorectal carcinoma cell lines.

Biological Activity

S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.

in vivo

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition^[1].

Animal Model:	Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells^[1]
Dosage:	10 mg/kg
Administration:	I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result:	Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors. The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

IC 50

CA Ⅸ

storage

Store at +4°C

CAIX Inhibitor S4 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAIX Inhibitor S4 Suppliers

China 41 United Kingdom 1 United States 5 Global 47

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9377
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
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Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 4023
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Shanghai Longyu Biotechnology Co., Ltd.

Tel: +8619521488211
Fax: +86 15821988213
Email: info@longyupharma.com
Country: China
ProdList: 2541
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View Lastest Price from CAIX Inhibitor S4 manufacturers

Shanghai Longyu Biotechnology Co., Ltd.

Product: S4 1330061-67-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99
Supply Ability: 20tons
Release date: 2022-01-18

Shanghai Chinqesen Biotechnology Co., Ltd.

Product: CAIX Inhibitor S4 1330061-67-0
Price: US $30.00-10.00/BOX
Min. Order: 10BOX
Purity: 99
Supply Ability: 20TONS
Release date: 2023-11-08

Hangzhou Huarong Pharm Co., Ltd.

Product: CAIX Inhibitor S4 1330061-67-0
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 99%
Supply Ability: 10KG
Release date: 2021-09-16

1330061-67-0, CAIX Inhibitor S4Related Search:

4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate

CAIX Inhibitor S4

Sulfamic acid, 4-[[[(3,5-dimethylphenyl)amino]carbonyl]amino]phenyl ester

S4 >=98% (HPLC)

4-(3-(3,5-Dimethylphenyl)ureido)phenyl sulfamate

CAIX Inhibitor S4, 10 mM in DMSO

1330061-67-0