ChemicalBook > CAS DataBase List > Z-ALA-ALA-ASN-AMC
Z-ALA-ALA-ASN-AMC
- Product Name
- Z-ALA-ALA-ASN-AMC
- CAS No.
- 149697-16-5
- Chemical Name
- Z-ALA-ALA-ASN-AMC
- Synonyms
- Z-AAN-AMC;Z-ALA-ALA-ASN-MCA;Z-ALA-ALA-ASN-AMC;BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE;L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate
- CBNumber
- CB3331600
- Molecular Formula
- C28H31N5O8
- Formula Weight
- 565.57
- MOL File
- 149697-16-5.mol
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Z-ALA-ALA-ASN-AMC Property
- Boiling point:
- 984.1±65.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 11.14±0.46(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
TRC
- Product number
- A576148
- Product name
- Z-ALA-ALA-ASN-AMC
- Packaging
- 2.5mg
- Price
- $65
- Updated
- 2021/12/16
TRC
- Product number
- A576148
- Product name
- Z-ALA-ALA-ASN-AMC
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA110589
- Product name
- Z-Ala-Ala-Asn-AMC
- Packaging
- 25mg
- Price
- $128
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA110589
- Product name
- Z-Ala-Ala-Asn-AMC
- Packaging
- 50mg
- Price
- $223
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA110589
- Product name
- Z-Ala-Ala-Asn-AMC
- Packaging
- 100mg
- Price
- $388
- Updated
- 2021/12/16
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Z-ALA-ALA-ASN-AMC Chemical Properties,Usage,Production
Uses
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].
References
[1] Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. DOI:10.1021/bc800448u
[2] James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
[3] Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035. DOI:10.1016/j.chembiol.2016.05.020
Z-ALA-ALA-ASN-AMC Preparation Products And Raw materials
Raw materials
Preparation Products
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Z-ALA-ALA-ASN-AMC Suppliers
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149697-16-5, Z-ALA-ALA-ASN-AMCRelated Search:
Z-ALA-ALA-LEU-PNA
RHODAMINE 110, BIS-(CBZ-L-ALANYL-L-ALANYL-L-ALANYL-L-ALANINE AMIDE)
PROTEASOME SUBSTRATE VI, FLUOROGENIC
Z-VAL-ALA-ASN-AMC
Z-ALA-ALA-ASN-AMC