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Z-ALA-ALA-ASN-AMC

Product Name
Z-ALA-ALA-ASN-AMC
CAS No.
149697-16-5
Chemical Name
Z-ALA-ALA-ASN-AMC
Synonyms
Z-AAN-AMC;Z-ALA-ALA-ASN-MCA;Z-ALA-ALA-ASN-AMC;BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE;L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate
CBNumber
CB3331600
Molecular Formula
C28H31N5O8
Formula Weight
565.57
MOL File
149697-16-5.mol
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Z-ALA-ALA-ASN-AMC Property

Boiling point:
984.1±65.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
Soluble in DMSO
form 
Solid
pka
11.14±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A576148
Product name
Z-ALA-ALA-ASN-AMC
Packaging
2.5mg
Price
$65
Updated
2021/12/16
TRC
Product number
A576148
Product name
Z-ALA-ALA-ASN-AMC
Packaging
5mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110589
Product name
Z-Ala-Ala-Asn-AMC
Packaging
25mg
Price
$128
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110589
Product name
Z-Ala-Ala-Asn-AMC
Packaging
50mg
Price
$223
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110589
Product name
Z-Ala-Ala-Asn-AMC
Packaging
100mg
Price
$388
Updated
2021/12/16
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Z-ALA-ALA-ASN-AMC Chemical Properties,Usage,Production

Uses

Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].

References

[1] Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. DOI:10.1021/bc800448u
[2] James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
[3] Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035. DOI:10.1016/j.chembiol.2016.05.020

Z-ALA-ALA-ASN-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

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149697-16-5, Z-ALA-ALA-ASN-AMCRelated Search:


  • BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE
  • Z-AAN-AMC
  • Z-ALA-ALA-ASN-AMC
  • Z-ALA-ALA-ASN-MCA
  • L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate
  • 149697-16-5
  • C28H31N5O8
  • peptide