ChemicalBook > CAS DataBase List > 3'-Azido-3'-deoxy-5-methylcytidine

3'-Azido-3'-deoxy-5-methylcytidine

Product Name
3'-Azido-3'-deoxy-5-methylcytidine
CAS No.
1282040-14-5
Chemical Name
3'-Azido-3'-deoxy-5-methylcytidine
Synonyms
3'-Azido-3'-deoxy-5-methylcytidin;3'-Azido-3'-deoxy-5-methylcytidine;3''-Azido-3''-deoxy-5-methylcytidine, 10 mM in DMSO;HIV,Inhibitor,inhibit,Human immunodeficiency virus,3'Azido3'deoxy5methylcytidine,Reverse Transcriptase,3' Azido 3' deoxy 5 methylcytidine
CBNumber
CB33334237
Molecular Formula
C10H14N6O4
Formula Weight
282.26
MOL File
1282040-14-5.mol
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3'-Azido-3'-deoxy-5-methylcytidine Property

storage temp. 
Store at -20°C
solubility 
DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0089191
Product name
3'-Azido-3'-deoxy-5-methylcytidine
Purity
99.39%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0089191
Product name
3'-Azido-3'-deoxy-5-methylcytidine
Purity
99.39%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0089191
Product name
3'-Azido-3'-deoxy-5-methylcytidine
Purity
99.39%
Packaging
100mg
Price
$750
Updated
2021/12/16
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3'-Azido-3'-deoxy-5-methylcytidine Chemical Properties,Usage,Production

Uses

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

HIV-1: 0.06 μM (EC50, in PBM cells); XMRV: 43.5 μM (CC50, in MCF-7 cells)

References

[1] Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948. DOI:10.1371/journal.pone.0009948

3'-Azido-3'-deoxy-5-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-Azido-3'-deoxy-5-methylcytidine Suppliers

China 29 United States 7 Global 36
T&W GROUP
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1282040-14-5, 3'-Azido-3'-deoxy-5-methylcytidineRelated Search:


  • 3'-Azido-3'-deoxy-5-methylcytidine
  • 3'-Azido-3'-deoxy-5-methylcytidin
  • HIV,Inhibitor,inhibit,Human immunodeficiency virus,3'Azido3'deoxy5methylcytidine,Reverse Transcriptase,3' Azido 3' deoxy 5 methylcytidine
  • 3''-Azido-3''-deoxy-5-methylcytidine, 10 mM in DMSO
  • 1282040-14-5