3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide

Product Name: 3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide
CAS No.: 76001-09-7
Chemical Name: 3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide
Synonyms: Antiulcer Agent 1;Antiulcer Agent 1, 10 mM in DMSO;3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide;Antiulcer Agent 1,inhibit,Inhibitor,Antiulcer Agent-1,Antiulcer Agent1;Benzamide, 3-[[2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]-
CBNumber: CB33339580
Molecular Formula: C19H23N3O4
Formula Weight: 357.40362
MOL File: 76001-09-7.mol

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3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide Chemical Properties,Usage,Production

Uses

Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new agent development.

in vivo

The hydrochloride form shows incompatibility with the excipients used for oral dosage forms. There are several crystal forms of the free base, namely, alpha-anhydrate, beta-anhydrate, monohydrate, and trihydrate. The trihydrate form is unstable. The degree of crystallinity of the beta-anhydrate form is difficult to control. The monohydrate form is difficult to manufacture with constant quality. The serum levels of the compounds in rats are almost related to the dissolution rates in the JP 1st disintegration medium from the discs. The serum level of alpha-anhydrate is the lowest^[1].

References

[1] Morita M, et al. Preliminary preformulation studies of a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new drug development. Chem Pharm Bull (Tokyo). 1995 Mar;43(3):476-82. DOI:10.1248/cpb.43.476

3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide Preparation Products And Raw materials

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Preparation Products

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3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide Suppliers

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76001-09-7, 3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamideRelated Search:

3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]benzamide

Antiulcer Agent 1

Benzamide, 3-[[2-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]-

Antiulcer Agent 1,inhibit,Inhibitor,Antiulcer Agent-1,Antiulcer Agent1

Antiulcer Agent 1, 10 mM in DMSO

76001-09-7