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FR-188582

Product Name
FR-188582
CAS No.
189699-82-9
Chemical Name
FR-188582
Synonyms
FR-188582;FR 188582,FR188582;1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-
CBNumber
CB33339656
Molecular Formula
C16H13ClN2O2S
Formula Weight
332.8
MOL File
189699-82-9.mol
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FR-188582 Property

Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
-3.80±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7185
Product name
FR-188582
Purity
99.21%
Packaging
1mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-7185
Product name
FR-188582
Purity
99.21%
Packaging
5mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-7185
Product name
FR-188582
Purity
99.21%
Packaging
10mg
Price
$1224
Updated
2021/12/16
ChemScene
Product number
CS-7185
Product name
FR-188582
Purity
99.21%
Packaging
20mg
Price
$2160
Updated
2021/12/16
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FR-188582 Chemical Properties,Usage,Production

Uses

FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM.

in vivo

Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED50 values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED50 values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively[1].

IC 50

COX-2: 17 nM (IC50)

References

[1] Ochi T, et al. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82. DOI:10.1254/jjp.85.175

FR-188582 Preparation Products And Raw materials

Raw materials

Preparation Products

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FR-188582 Suppliers

China 10 United States 4 Global 14
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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cjbscvictory
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13348960310
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3003867561@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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24961
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Suzhou Zhixin Biotechnology Co., Ltd.
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0512-65118909 18100677375
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sales@szzxbio.com
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China
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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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021-59167510 18117107507
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vip@med-life.cn
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China
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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189699-82-9, FR-188582Related Search:


  • FR-188582
  • 1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-
  • FR 188582,FR188582
  • 189699-82-9