CWP232228

Product Name: CWP232228
CAS No.: 1144044-02-9
Chemical Name: CWP232228
Synonyms: CWP232228;CWP232228?sodium;CWP232228 disodium;Beta catenin,Wnt,Breast,β-catenin,Inhibitor,CWP232228,CWP 232228,cells,signaling,stem,Cancer,inhibit,liver,CWP-232228;Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate
CBNumber: CB33354107
Molecular Formula: C33H37N7NaO7P
Formula Weight: 697.66
MOL File: 1144044-02-9.mol

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CWP232228 Property

form: Solid
color: White to off-white
InChIKey: RCZZPLXBWBXLAA-RYRAPZCFNA-N
SMILES: C(N1N(CC(=O)N2[C@H](C(=O)N(CC3=CC=CC4=CN(C)N=C34)C[C@]12[H])CC1C=CC(OP(O)(O)=O)=CC=1)CC=C)(=O)NCC1C=CC=CC=1.[NaH] |&1:7,23,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0014678
Product name: CWP232228
Purity: 98.31%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0014678
Product name: CWP232228
Purity: 98.31%
Packaging: 10mg
Price: $980
Updated: 2021/12/16

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CWP232228 Chemical Properties,Usage,Production

Uses

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].

in vivo

CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume^[1].

Animal Model:	7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors^[1]
Dosage:	100 mg/kg
Administration:	Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors
Result:	Treatment resulted in a significant reduction in tumor volume.

References

[1] Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75(8):1691-702. DOI:10.1158/0008-5472.CAN-14-2041
[2] Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. DOI:10.18632/oncotarget.7954

CWP232228 Preparation Products And Raw materials

Raw materials

Preparation Products

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CWP232228 Suppliers

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1144044-02-9, CWP232228Related Search:

CWP232228

CWP232228?sodium

CWP232228 disodium

Beta catenin,Wnt,Breast,β-catenin,Inhibitor,CWP232228,CWP 232228,cells,signaling,stem,Cancer,inhibit,liver,CWP-232228

Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate

1144044-02-9