VU 0409551
- Product Name
- VU 0409551
- CAS No.
- 1363281-27-9
- Chemical Name
- VU 0409551
- Synonyms
- VU 0409551;JNJ-46778212;JNJ 46778212,JNJ46778212;JNJ-46778212, 10 mM in DMSO;[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone;(4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone;Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
- CBNumber
- CB33354233
- Molecular Formula
- C20H17FN2O3
- Formula Weight
- 352.36
- MOL File
- 1363281-27-9.mol
VU 0409551 Property
- Boiling point:
- 545.8±50.0 °C(Predicted)
- Density
- 1.308±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble; Ethanol: soluble
- form
- A crystalline solid
- pka
- 1.35±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML2783
- Product name
- VU0409551
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $73.62
- Updated
- 2025/07/31
- Product number
- SML2783
- Product name
- VU0409551
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $372.4
- Updated
- 2025/07/31
- Product number
- 18042
- Product name
- VU0409551
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18042
- Product name
- VU0409551
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 18042
- Product name
- VU0409551
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
VU 0409551 Chemical Properties,Usage,Production
Uses
VU 0409551 is an mGlu5 allosteric modulator.
Biological Activity
VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.
in vivo
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].
IC 50
mGlu5 Receptor: 260 nM (EC50)
storage
Store at +4°C
VU 0409551 Preparation Products And Raw materials
Raw materials
Preparation Products
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