1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene

Product Name: 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene
CAS No.: 6683-48-3
Chemical Name: 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene
Synonyms: 6-Pentamethyl-1;Bexarotene Impurity 14;2-methyl-5,6,7,8-tetrahydro-;1,1,4,4,6-Pentamethyltetralin;1,1,4,4,6-Pentamethyl-1,2,3,4-;1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaph;1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydrophthalene;1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene;1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene;1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE
CBNumber: CB3335653
Molecular Formula: C15H22
Formula Weight: 202.34
MOL File: 6683-48-3.mol

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1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Property

Melting point:: 31
Boiling point:: 60-64°C 0,2mm
Density: 0.882±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
color: Colourless to Pale Yellow Oil
InChI: InChI=1S/C15H22/c1-11-6-7-12-13(10-11)15(4,5)9-8-14(12,2)3/h6-7,10H,8-9H2,1-5H3
InChIKey: AISXBZVAYNUAKB-UHFFFAOYSA-N
SMILES: C1(C)(C)C2=C(C=C(C)C=C2)C(C)(C)CC1

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2917399590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: B665
Product name: 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethyl-naphthalene
Packaging: 1g
Price: $14
Updated: 2021/12/16

Matrix Scientific

Product number: 024956
Product name: 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene
Purity: 95%
Packaging: 5g
Price: $34
Updated: 2021/12/16

Matrix Scientific

Product number: 024956
Product name: 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene
Purity: 95%
Packaging: 25g
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: B665
Product name: 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethyl-naphthalene
Packaging: 25g
Price: $114
Updated: 2021/12/16

ChemScene

Product number: CS-B0383
Product name: 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene
Purity: ≥99.0%
Packaging: 100g
Price: $122
Updated: 2021/12/16

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1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Targretin analog, has been shown to induce apoptosis in certain leukemia cell lines.

Synthesis

6223-78-5

108-88-3

6683-48-3

1. In a dry reaction flask, dissolve 2,5-dichloro-2,5-dimethylhexane (10 g, 54.7 mmol) in toluene (270 mL) and stir until completely dissolved. 2. slowly add anhydrous aluminum trichloride (5.47 g, 41 mmol) to the above solution in batches over 15 minutes, taking care to control the addition rate to avoid intense exotherm. 3. After the addition, the reaction was continued with stirring for 10 minutes, and the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: hexane) to confirm the completion of the reaction. 4. Under cooling in an ice bath, slowly add water dropwise (~10 min) to quench the unreacted aluminum trichloride, taking care to control the rate of dropwise acceleration to avoid intense exotherm. 5. The reaction mixture is extracted with toluene (250 mL) and the organic layer is separated. 6. The organic layer was filtered through a silica gel pad (40 g) and eluted with toluene to remove possible polar impurities. 7. The organic phases were combined and concentrated to dryness under reduced pressure to afford the crude product 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene (11 g, 97% yield). 8. The product was characterized by nuclear magnetic resonance hydrogen spectroscopy (1H NMR): δ 1.29 (s, 6H), 1.28 (s, 6H), 1.69 (s, 4H), 2.32 (s, 3H), 7.22 (d, 1H), 7.12 (s, 1H), 6.97 (dd, 1H).

References

[1] Journal of Organic Chemistry, 1991, vol. 56, # 15, p. 4706 - 4713
[2] Journal of Organic Chemistry, 2001, vol. 66, # 17, p. 5772 - 5782
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 23, p. 3467 - 3470
[4] Patent: US2004/10033, 2004, A1. Location in patent: Page/Page column 11
[5] Patent: WO2003/106446, 2003, A1. Location in patent: Page 19-20

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Suppliers

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View Lastest Price from 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE 6683-48-3
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2025-06-13

Career Henan Chemical Co

Product: 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene 6683-48-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: as request
Release date: 2018-12-22

6683-48-3, 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthaleneRelated Search:

Decahydronaphthalene 2,6-DIMETHYLNAPHTHALENE Pyrrolidine 1,2,3,4-Tetrahydronaphthalene 2-Methylnaphthalene TTNPB (Arotinoid Acid) 6-ACETYL-1,1,2,4,4,7-HEXAMETHYLTETRALIN 2-BROMO-1-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE Hexamethylenetetramine linarotene 3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALENE-2-BORONIC ACID 6-BROMO-1,1,4,4,7-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE,6-Bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene 98% 1,1,4,4,5,5,8,8-OCTAMETHYL-1,2,3,4,5,6,7,8-OCTAHYDROANTHRACENE 1-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE 1-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE OXIME 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID 2-BROMO-1-(3-ETHYL-5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE 6-(CHLOROMETHYL)-1,1,4,4-TETRAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE

1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaph

Bexarotene Impurity 14

1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene

1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHALENE

1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHYLENE

1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE

1,1,4,4,6-Pentamethyltetralin

1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene, tech

1,1,4,4,6-Pentamethyl-1,2,3,4-

1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTALENE: TECH.

Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4,6-pentaMethyl-

2-Methyl-5,6,7,8-tetrahydro- 5,5,8,8-tetraMethyl naphthalene

2-methyl-5,6,7,8-tetrahydro-

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydrophthalene

1,2,3,4-Tetrahydro-1,1,2,2,6-pentamethylnaphthalene

6-Pentamethyl-1

6683-48-3

C15H22

Fused Ring Systems

Aromatics

Heterocycles

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