ChemicalBook > CAS DataBase List > 5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Product Name
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS No.
1584121-99-2
Chemical Name
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Synonyms
IT901;IT 901,IT901;IT 901;IT901;IT-901;1584121-99-2;5-[(2,4-dimethoxynaphthalen-1-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione;5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;4,6(1H,5H)-Pyrimidinedione, 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-
CBNumber
CB33364216
Molecular Formula
C17H14N2O4S
Formula Weight
342.37
MOL File
1584121-99-2.mol
More
Less

5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:33.0(Max Conc. mg/mL);96.39(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);96.39(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.41(Max Conc. mM)
form 
A crystalline solid
pka
4.68±0.20(Predicted)
color 
Orange to red
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22298
Product name
IT-901
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22298
Product name
IT-901
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22298
Product name
IT-901
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
22298
Product name
IT-901
Purity
≥98%
Packaging
50mg
Price
$911
Updated
2024/03/01
Tocris
Product number
5846
Product name
IT901
Purity
≥98%(HPLC)
Packaging
50
Price
$861
Updated
2021/12/16
More
Less

5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Chemical Properties,Usage,Production

Uses

IT 901 is a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-?Rel. IT 901 also revealed antitumor properties in vitro and in vivo.

in vivo

IT-901 (24 mg/kg; IP; every other day for 2 weeks) has an effective treatment of acute GVHD without impairing anti-tumor activity[1].
IT-901 (12-20 mg/kg; IP) improves the PK profile by increasing T1/2 and Cmax[1].

Animal Model:BALB/C-Tg (NFkB-RE-luc)-Xen mice with 6-9 weeks old[1]
Dosage:24 mg/kg
Administration:IP; every other day for 2 weeks
Result:Had an effective treatment of acute GVHD without impairing anti-tumor activity.

IC 50

NF-κB: 0.1 μM (IC50); c-Rel: 3 μM (IC50)

5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Suppliers

China 45 United Kingdom 1 United States 6 USA 1 Global 53
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58

1584121-99-2, 5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneRelated Search:


  • 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
  • IT 901;IT901;IT-901;1584121-99-2
  • 5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
  • IT901
  • 4,6(1H,5H)-Pyrimidinedione, 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-
  • IT 901,IT901
  • 5-[(2,4-dimethoxynaphthalen-1-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
  • 1584121-99-2