AZD-4205

Product Name: AZD-4205
CAS No.: 2091134-68-6
Chemical Name: AZD-4205
Synonyms: NC-0322;AZD-4205;DZD-4205;JAK1-IN-3;Golidocitinib;JAK1 inhibitor 3;AZD 4205 (AZD4205);Afobazole Impurity 14;Golidocitinib (AZD-4205);Golidocitinib, 10 mM in DMSO
CBNumber: CB33364605
Molecular Formula: C25H31N9O2
Formula Weight: 489.58
MOL File: 2091134-68-6.mol

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AZD-4205 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 14.63±0.30(Predicted)
color: Light yellow to yellow
InChIKey: CVCVOSPZEVINRM-QEIABERDNA-N
SMILES: N(C1C=CC=C2C(C3C=CN=C(NC4=CN(C)N=C4OC)N=3)=CNC=12)C(=O)[C@H](N1CCN(C)CC1)C |&1:27,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028212
Product name: AZD4205
Purity: 99.32%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0028212
Product name: AZD4205
Purity: 99.32%
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-0028212
Product name: AZD4205
Purity: 99.32%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-0028212
Product name: AZD4205
Purity: 99.32%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573442
Product name: AZD 4205
Packaging: 100mg
Price: $1802
Updated: 2021/12/16

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AZD-4205 Chemical Properties,Usage,Production

Uses

Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM)[1].

in vivo

Golidocitinib (12.5 mg/kg BID (twice daily), 25 m/kg BID or 50 mg/kg BID, p.o.) alone has increasing antitumor effects, and ehances the antitumor activity of osimertinib, compared to treatment with osimertinib alone in mice bearing NCI-H1975 cells^[1].

IC 50

JAK1: 73 nM (IC₅₀)

References

[1] Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak. WO2017050938A1.

AZD-4205 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-4205 Suppliers

China 56 United States 3 Global 59

Changzhou Borl Biotechnology Co.,LTD

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CAREBIO PHARMA

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Zhengzhou Haode Pharmaceutical Technology Co.,Ltd

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Heze Development Zone chuangli Chemical Co., Ltd.

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Jurong Coupling Biotechnology Co., Ltd.

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Shanghai Changyu Medical Technology Co. Ltd.

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2091134-68-6, AZD-4205Related Search:

AZD-4205

JAK1 inhibitor 3

AZD 4205 (AZD4205)

JAK1-IN-3

1-Piperazineacetamide, N-[3-[2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,4-dimethyl-, (αR)-

Golidocitinib

AZD 4205,Janus kinase,Golidocitinib,AZD-4205,JAK,Inhibitor,inhibit

(2R)-N-(3-{2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide

Golidocitinib (AZD-4205)

(R)-N-(3-(2-((3-Methoxy-1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide

Afobazole Impurity 14

Golidocitinib, 10 mM in DMSO

DZD-4205

NC-0322

2091134-68-6