ChemicalBook > CAS DataBase List > 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)

Product Name
2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)
CAS No.
173653-47-9
Chemical Name
2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)
Synonyms
Monomethyl auristatin E intermediate-15;benzyl (2S,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate;tert-butyl (S)-2-((1R,2S)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate;2-Pyrrolidinepropanoicacid,1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-,phenylmethylester,[2S-[2R*(αR*,βS*)]]-(9CI);2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)
CBNumber
CB33367338
Molecular Formula
C20H29NO5
Formula Weight
363.45
MOL File
173653-47-9.mol
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2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) Property

Boiling point:
492.3±20.0 °C(Predicted)
Density 
1.156±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
Oil
pka
13.99±0.20(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) Chemical Properties,Usage,Production

Uses

Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

References

[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931

2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI) Suppliers

China 3 Global 3
Hangzhou Huarong Pharm Co., Ltd.
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571-86758373 +8613588754946
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0086-571-81131109
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sales@huarongpharm.com
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Shanghai Kaiwei Chemical Technology Co., Ltd.
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021-58461859 15821823057
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China
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Shanghai Haohong Pharmaceutical Co., Ltd.
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400-8210725 4008210725
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173653-47-9, 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)Related Search:


  • 2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-, phenylmethyl ester, [2S-[2R*(αR*,βS*)]]- (9CI)
  • tert-butyl (S)-2-((1R,2S)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
  • benzyl (2S,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate
  • 2-Pyrrolidinepropanoicacid,1-[(1,1-dimethylethoxy)carbonyl]-β-hydroxy-α-methyl-,phenylmethylester,[2S-[2R*(αR*,βS*)]]-(9CI)
  • Monomethyl auristatin E intermediate-15
  • 173653-47-9