ONC212
- Product Name
- ONC212
- CAS No.
- 1807861-48-8
- Chemical Name
- ONC212
- Synonyms
- ONC212;DUN61488;ONC212 ，S8673;ONC 212;ONC-212;ONC212, 10 mM in DMSO;ONC 212;ONC-212;ONC212;1807861-48-8;ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis;7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one;Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-
- CBNumber
- CB33367929
- Molecular Formula
- C24H23F3N4O
- Formula Weight
- 440.46
- MOL File
- 1807861-48-8.mol
ONC212 Property
- Boiling point:
- 549.9±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:1.0(Max Conc. mg/mL);2.27(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);57.89(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.57(Max Conc. mM) - form
- A crystalline solid
- pka
- 6.22±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- O656510
- Product name
- ONC212
- Packaging
- 2.5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- DC11417
- Product name
- ONC212
- Purity
- >98%
- Packaging
- 250mg
- Price
- $950
- Updated
- 2021/12/16
ONC212 Chemical Properties,Usage,Production
Uses
ONC212, is an analogue of ONC201 (H291055), that is shown to a promising anti-cancer drug and also a selective agonist of GPR132.
in vivo
Biweekly oral administration of 50 mg/kg ONC212 markedly inhibits Acute myeloid leukemia (AML) expansion and prolongs overall survival (p=0.0003). Median survival increases from 43 d in controls to 49 d in the ONC212-treated group (+14%)[1].
ONC212 treatment exhibits significantly greater growth inhibition in comparison to ONC201. A dose of 50 mg/kg of ONC212 administered three-times a week is sufficient to lead to significant growth inhibition of tumors compare to the control group for these two models. Results demonstrate that ONC212 treated tumors show reduced proliferation in the HPAF-II model[2].
In vivo toxicity assessment experiments show that ONC212 is well tolerated up to 250 mg/kg. 300 mg/kg of ONC212 causes splenic damage and elevates liver enzymes. ONC212 has a slightly shorter half-life than ONC201, with a clearance from the blood at 12 hours, T1/2 of 4.3 hours, and Cmax of 1.4 μg/mL[3].
ONC212 Preparation Products And Raw materials
Raw materials
Preparation Products
ONC212 Suppliers
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View Lastest Price from ONC212 manufacturers
- Product
- ONC212 1807861-48-8
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-18