ChemicalBook > CAS DataBase List > ONC212

ONC212

Product Name: ONC212
CAS No.: 1807861-48-8
Chemical Name: ONC212
Synonyms: ONC212;DUN61488;ONC212 ，S8673;ONC 212;ONC-212;ONC212, 10 mM in DMSO;ONC 212;ONC-212;ONC212;1807861-48-8;ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis;7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one;Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-
CBNumber: CB33367929
Molecular Formula: C24H23F3N4O
Formula Weight: 440.46
MOL File: 1807861-48-8.mol

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ONC212 Property

Boiling point:: 549.9±60.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:1.0(Max Conc. mg/mL);2.27(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);57.89(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.57(Max Conc. mM)
form: A crystalline solid
pka: 6.22±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

TRC

Product number: O656510
Product name: ONC212
Packaging: 2.5mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC11417
Product name: ONC212
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

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ONC212 Chemical Properties,Usage,Production

Uses

ONC212, is an analogue of ONC201 (H291055), that is shown to a promising anti-cancer drug and also a selective agonist of GPR132.

in vivo

Biweekly oral administration of 50 mg/kg ONC212 markedly inhibits Acute myeloid leukemia (AML) expansion and prolongs overall survival (p=0.0003). Median survival increases from 43 d in controls to 49 d in the ONC212-treated group (+14%)^[1].
ONC212 treatment exhibits significantly greater growth inhibition in comparison to ONC201. A dose of 50 mg/kg of ONC212 administered three-times a week is sufficient to lead to significant growth inhibition of tumors compare to the control group for these two models. Results demonstrate that ONC212 treated tumors show reduced proliferation in the HPAF-II model^[2].
In vivo toxicity assessment experiments show that ONC212 is well tolerated up to 250 mg/kg. 300 mg/kg of ONC212 causes splenic damage and elevates liver enzymes. ONC212 has a slightly shorter half-life than ONC201, with a clearance from the blood at 12 hours, T_1/2 of 4.3 hours, and C_max of 1.4 μg/mL^[3].

ONC212 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ONC212 manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: ONC212 1807861-48-8
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-18

1807861-48-8, ONC212Related Search:

ONC212

ONC 212;ONC-212;ONC212;1807861-48-8

ONC 212;ONC-212

Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-

7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

DUN61488

ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis

ONC212, 10 mM in DMSO

ONC212 ，S8673

1807861-48-8

APIs