iRGD
- Product Name
- iRGD
- CAS No.
- 1392278-76-0
- Chemical Name
- iRGD
- Synonyms
- c(CRGDKGPDC);iRGD;iRGD TFA;iGRD peptide;H-CRGDKGPDC-OH;H-CRGDKGPDC-NH2;iGRD peptide acetate;iRGD peptide TFA salt;inhibit,Inhibitor,iRGD peptide,Integrin;L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide
- CBNumber
- CB33368577
- Molecular Formula
- C35H57N13O14S2
- Formula Weight
- 948.04
- MOL File
- 1392278-76-0.mol
iRGD Property
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- DMSO: Soluble: =10 mg/mlPBS (pH 7.2): Soluble: =10 mg/ml
- form
- Solid
- pka
- 2.92±0.70(Predicted)
- color
- White to off-white
- Water Solubility
- Water : ≥ 50 mg/mL (52.74 mM)
- Sequence
- H-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide bridge: Cys1-Cys9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0019023
- Product name
- iRGDpeptide
- Purity
- 99.03%
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0019023
- Product name
- iRGDpeptide
- Purity
- 99.03%
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CS-0019023
- Product name
- iRGDpeptide
- Purity
- 99.03%
- Packaging
- 10mg
- Price
- $620
- Updated
- 2021/12/16
iRGD Chemical Properties,Usage,Production
Uses
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
in vivo
iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2].
References
[1] Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. DOI:10.1038/gt.2014.52
[2] Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143. DOI:10.1016/j.biopha.2017.06.103
[3] LU LU. Mitochondrial Metabolism Targeted Nanoplatform for Efficient Triple-Negative Breast Cancer Combination Therapy[J]. Advanced Healthcare Materials, 2021, 10 20. DOI: 10.1002/adhm.202100978
[4] YAO Y, SAW P E, NIE Y, et al. Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy†[J]. Journal of Materials Chemistry B, 2018, 4: 576-585. DOI: 10.1039/c8tb02600a
iRGD Preparation Products And Raw materials
Raw materials
Preparation Products
iRGD Suppliers
- Tel
- 89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9416
- Advantage
- 55
- Tel
- 025-83697070 13770331960
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
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- 16027
- Advantage
- 64
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7777
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 233
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- Tel
- info@creative-peptides.com
- Country
- United States
- ProdList
- 6083
- Advantage
- 56
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
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- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
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- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29661
- Advantage
- 68
- Tel
- +86-17380623303 +86-17380623303;
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4801
- Advantage
- 58
View Lastest Price from iRGD manufacturers
- Product
- Irgd 1392278-76-0
- Price
- US $0.00/g
- Min. Order
- 50g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-17
- Product
- Opiorphin 1392278-76-0
- Price
- US $0.00/g
- Min. Order
- 50g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-04-17
- Product
- iRGD 1392278-76-0
- Price
- US $24.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 20000
- Release date
- 2024-04-11