iRGD

Product Name: iRGD
CAS No.: 1392278-76-0
Chemical Name: iRGD
Synonyms: c(CRGDKGPDC);iRGD;iRGD TFA;iGRD peptide;H-CRGDKGPDC-OH;H-CRGDKGPDC-NH2;iGRD peptide acetate;iRGD peptide TFA salt;inhibit,Inhibitor,iRGD peptide,Integrin;L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide
CBNumber: CB33368577
Molecular Formula: C35H57N13O14S2
Formula Weight: 948.04
MOL File: 1392278-76-0.mol

More

Less

iRGD Property

Density: 1.68±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: DMSO: Soluble: =10 mg/mlPBS (pH 7.2): Soluble: =10 mg/ml
form: Solid
pka: 2.92±0.70(Predicted)
color: White to off-white
Water Solubility: Water : ≥ 50 mg/mL (52.74 mM)
Sequence: H-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide bridge: Cys1-Cys9)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0019023
Product name: iRGDpeptide
Purity: 99.03%
Packaging: 1mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0019023
Product name: iRGDpeptide
Purity: 99.03%
Packaging: 5mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-0019023
Product name: iRGDpeptide
Purity: 99.03%
Packaging: 10mg
Price: $620
Updated: 2021/12/16

More

Less

iRGD Chemical Properties,Usage,Production

Uses

iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

in vivo

iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice^[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells^[2].

References

[1] Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. DOI:10.1038/gt.2014.52
[2] Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143. DOI:10.1016/j.biopha.2017.06.103
[3] LU LU. Mitochondrial Metabolism Targeted Nanoplatform for Efficient Triple-Negative Breast Cancer Combination Therapy[J]. Advanced Healthcare Materials, 2021, 10 20. DOI: 10.1002/adhm.202100978
[4] YAO Y, SAW P E, NIE Y, et al. Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy†[J]. Journal of Materials Chemistry B, 2018, 4: 576-585. DOI: 10.1039/c8tb02600a

iRGD Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

iRGD Suppliers

China 104 India 1 United States 6 Global 111

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9401
Advantage: 55

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15778
Advantage: 64

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Hangzhou Peptide Biochem Co.,Ltd

Tel: 0571-89197072; 18668118770
Fax: 0571-89197072
Email: linda@peptide-china.com
Country: China
ProdList: 235
Advantage: 56

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9497
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29662
Advantage: 68

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Email: 13419635609@163.com
Country: China
ProdList: 1984
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

More

Less

View Lastest Price from iRGD manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Irgd 1392278-76-0
Price: US $0.00/g
Min. Order: 50g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-04-17

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Opiorphin 1392278-76-0
Price: US $0.00/g
Min. Order: 50g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-04-17

Shanghai Getian Industrial Co., LTD

Product: iRGD 1392278-76-0
Price: US $24.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 20000
Release date: 2024-04-11

1392278-76-0, iRGDRelated Search:

iRGD

c(CRGDKGPDC)

L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide

iRGD TFA

iRGD peptide TFA salt

inhibit,Inhibitor,iRGD peptide,Integrin

2,2'-((3S,6R,11R,14S,20S,23S,31aS)-11-amino-23-(4-aminobutyl)-6-carboxy-14-(3-guanidinopropyl)-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosine-3,20-diyl)diacetic acid

iGRD peptide

iGRD peptide acetate

H-CRGDKGPDC-OH

H-CRGDKGPDC-NH2

1392278-76-0