ARVANIL Property

Boiling point:

619.4±55.0 °C(Predicted)

Density 

1.002±0.06 g/cm3(Predicted)

Flash point:

14℃

storage temp. 

-20°C

solubility 

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

pka

9.76±0.20(Predicted)

form 

liquid

color 

colorless to pale yellow

Safety

RIDADR 

UN1170 - class 3 - PG 2 - Ethanol

WGK Germany 

3

RTECS 

JX3845000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

ARVANIL Chemical Properties,Usage,Production

Uses

Arvanil is a cannabinoid CB1?and vanilloid TRPV1 (VR) agonist.

Definition

ChEBI: N-arachidonoyl vanillylamine is a member of phenols and a member of methoxybenzenes.

Biological Activity

Cannabinoid CB 1 and vanilloid TRPV1 (VR1) agonist (K i values are 0.5 and 0.3 μ M respectively). Also inhibits the anandamide transporter (IC 50 = 3.6 μ M). Analgesic, vasodilatory and anti-inflammatory in vivo .

Biochem/physiol Actions

Arvanil is an activator of cannabinoid and vanilloid receptors, and a potent inhibitor of anandamide accumulation. Arvanil inhibits growth of astrocytoma xenograft tumors in mice, mimicing the effect of neural precursor cells, that have been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids.