ALB-127158
- Product Name
- ALB-127158
- CAS No.
- 1173154-32-9
- Chemical Name
- ALB-127158
- Synonyms
- ALB-127158;ALB-127158A;4-((5-fluoropyridin-2-yl)methoxy)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one;2(1H)-Pyridinone, 4-[(5-fluoro-2-pyridinyl)methoxy]-1-(2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-7-yl)-;ALB-127158A; ALB 127158A; ALB127158A; ALB-127158(A); ALB127158(A); ALB 127158(A); ALB-127158; ALB 127158; ALB127158;1173154-32-9
- CBNumber
- CB33370574
- Molecular Formula
- C23H21FN4O2
- Formula Weight
- 404.44
- MOL File
- 1173154-32-9.mol
ALB-127158 Property
- Boiling point:
- 660.3±55.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol : 2 mg/mL (4.95 mM)
- form
- Solid
- pka
- 10.33±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- A512005
- Product name
- ALB127158(a)
- Packaging
- 1mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- A512005
- Product name
- ALB127158(a)
- Packaging
- 2.5mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CS-0040331
- Product name
- ALB-127158(a)
- Purity
- 99.32%
- Packaging
- 10mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0040331
- Product name
- ALB-127158(a)
- Purity
- 99.32%
- Packaging
- 50mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- CS-0040331
- Product name
- ALB-127158(a)
- Purity
- 99.32%
- Packaging
- 100mg
- Price
- $1500
- Updated
- 2021/12/16
ALB-127158 Chemical Properties,Usage,Production
Uses
ALB 127158(a), is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.
in vivo
In a mouse diet induced obesity (DIO) model, ALB-127158(a) produces a significant sustained decrease in body weight and food intake in the range of 5-15 mg/kg bid. The weight reduction is predominantly due to a decrease in fat content. In high fat diet (HFD) rats, ALB-127158(a) produces significant weight loss and food reduction at doses as low as 1.25 mg/kg po. Doses > 1.25 mg/kg po produces weight loss > 6%, maximal weight loss of about 10% in rats is observed at 10 mg/kg. Following single and multiple oral administration of ALB-127158(a), ALB-127158(a) is rapidly absorbed (median tmax attains between 1 and 3 h post dose in lean and overweight/obese subjects) with a trend to decrease over dose suggesting a slower absorption rate of ALB-127158(a) at lower doses. After single doses, ALB-127158(a) has a mean half-life (t1/2) of 18 to 21 h. Slightly longer mean t1/2 estimates of approximately 26 h are obtained following multiple dosing in overweight/obese subjects; steady-state plasma ALB-127158(a) is attained within 6 to 8 days of dosing[1].
ALB-127158 Preparation Products And Raw materials
Raw materials
Preparation Products
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