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ETC-206

Product Name
ETC-206
CAS No.
1464151-33-4
Chemical Name
ETC-206
Synonyms
ETC-206;Tinodasertib;ETC-1907206);ETC-206 (ETC206;ETC-206 (AUM 001);Tinodasertib (ETC-206);ETC-206, 10 mM in DMSO;ETC-206 (AUM 001) ，S6658;4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile;Benzonitrile, 4-[6-[4-(4-morpholinylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]-
CBNumber
CB33370680
Molecular Formula
C25H20N4O2
Formula Weight
408.45
MOL File
1464151-33-4.mol
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ETC-206 Property

storage temp. 
Store at -20°C
solubility 
DMSO:66.0(Max Conc. mg/mL);161.58(Max Conc. mM)
form 
A solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0046041
Product name
ETC-206
Purity
99.76%
Packaging
5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0046041
Product name
ETC-206
Purity
99.76%
Packaging
10mg
Price
$340
Updated
2021/12/16
Axon Medchem
Product number
Axon3340
Product name
ETC-206
Purity
99%
Packaging
25mg
Price
$506
Updated
2021/12/16
ChemScene
Product number
CS-0046041
Product name
ETC-206
Purity
99.76%
Packaging
25mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0046041
Product name
ETC-206
Purity
99.76%
Packaging
50mg
Price
$980
Updated
2021/12/16
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ETC-206 Chemical Properties,Usage,Production

Uses

Tinodasertib (ETC-206) is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.

in vivo

The antitumor effect of ETC-206 is then assessed in a K562 e/o eIF4E mouse xenograft model after oral administration at 25, 50, or 100 mg/kg alone or in combination with a 2.5 mg/kg fixed dose of Dasatinib throughout the study. Dasatinib at 2.5 mg/kg elicits a tumor growth inhibition (TGI) of 88% with one tumor-free animal. In contrast, ETC-206 alone only yields a maximum TGI of 23% at the highest administered dose of 100 mg/kg, which does not impede tumor growth, and is similar to the nontreated animals. ETC-206 with 2.5 mg/kg of Dasatinib not only increases tumor growth inhibition in a dose-dependent manner but, more importantly leads to 2, 5, and 8 out of 8 tumor-free animals at 25, 50, and 100 mg/kg, respectively. The combination of ETC-206 and Dasatinib inhibits tumor growth at all tested doses, and no weight loss is recorded. Both the combination of ETC-206 and Dasatinib and, on the other hand, the dual MNK1/2 and BCR-ABL1 inhibitors prevent tumor growth in the same mouse xenograft model. ETC-206 has moderate terminal elimination half-life (t1/2=1.7 h, and 1.77 h for mouse (1 mg/kg, i.v.), mouse (5 mg/kg, p.o.))[1].

IC 50

MNK1: 64 nM (IC50); MNK2: 86 nM (IC50)

References

[1] Yang H, et al. Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. J Med Chem. 2018 May 24;61(10):4348-4369. DOI:10.1021/acs.jmedchem.7b01714

ETC-206 Preparation Products And Raw materials

Raw materials

Preparation Products

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ETC-206 Suppliers

CHINA 59 United States 4 Global 63
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
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China
ProdList
310
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
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58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
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58
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58

1464151-33-4, ETC-206Related Search:


  • ETC-206
  • ETC-1907206)
  • ETC-206 (ETC206
  • Benzonitrile, 4-[6-[4-(4-morpholinylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]-
  • ETC-206 (AUM 001)
  • MAP kinase interacting kinase,Inhibitor,MNK,ETC206,inhibit,ETC-206,MAPK interacting kinase,ETC 206,Mitogen activated protein kinase interacting kinase
  • 4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile
  • Tinodasertib
  • ETC-206, 10 mM in DMSO
  • Tinodasertib (ETC-206)
  • ETC-206 (AUM 001) ，S6658
  • 1464151-33-4