11-amino- Undecanoic acid, 1,1-dimethylethyl ester
- Product Name
- 11-amino- Undecanoic acid, 1,1-dimethylethyl ester
- CAS No.
- 220851-29-6
- Chemical Name
- 11-amino- Undecanoic acid, 1,1-dimethylethyl ester
- Synonyms
- tert-Butyl 11-aminoundecanoate;11-amino- Undecanoic acid, 1,1-dimethylethyl ester;Undecanoic acid, 11-amino-, 1,1-dimethylethyl ester;tertButyl 11aminoundecanoate,linker,PEG,PROTAC Linkers,tert Butyl 11 aminoundecanoate,Inhibitor,composition,inhibit,PROTAC
- CBNumber
- CB33377649
- Molecular Formula
- C15H31NO2
- Formula Weight
- 257.41
- MOL File
- 220851-29-6.mol
11-amino- Undecanoic acid, 1,1-dimethylethyl ester Property
- Boiling point:
- 328.9±15.0 °C(Predicted)
- Density
- 0.908±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- form
- Liquid
- pka
- 10.67±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS00991
- Product name
- tert-Butyl11-aminoundecanoate
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $302.5
- Updated
- 2021/12/16
11-amino- Undecanoic acid, 1,1-dimethylethyl ester Chemical Properties,Usage,Production
Uses
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
Alkyl/ether
References
[1] Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654. DOI:10.1038/s41598-019-56177-5
11-amino- Undecanoic acid, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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