NITD-349
- Product Name
- NITD-349
- CAS No.
- 1473450-62-2
- Chemical Name
- NITD-349
- Synonyms
- NITD-349;NITD-349, 10 mM in DMSO;inhibit,Bacterial,NITD349,NITD-349,NITD 349,Inhibitor;N-(4,4-Dimethylcyclohexyl)-4,6-difluoro-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, N-(4,4-dimethylcyclohexyl)-4,6-difluoro-
- CBNumber
- CB33384782
- Molecular Formula
- C17H20F2N2O
- Formula Weight
- 306.35
- MOL File
- 1473450-62-2.mol
NITD-349 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 310 mg/mL (1011.91 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N900620
- Product name
- NITD-349
- Packaging
- 5mg
- Price
- $470
- Updated
- 2021/12/16
- Product number
- CS-0032639
- Product name
- NITD-349
- Purity
- 98.84%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0032639
- Product name
- NITD-349
- Purity
- 98.84%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0032639
- Product name
- NITD-349
- Purity
- 98.84%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0032639
- Product name
- NITD-349
- Purity
- 98.84%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
NITD-349 Chemical Properties,Usage,Production
Uses
NITD-349, shows bactericidal activity against in vitro replicating Mycobacterium tuberculosis (Mtb) and also are active against intramacrophage Mtb.
in vivo
In the acute murine efficacy modelNITD-349 shows favorable oral pharmacokinetic (PK) properties in rodents and dogs and are efficacious in mouse models of both acute and chronic Mycobacterium tuberculosisinfection. In the acute murine efficacy model, treatment of mice with NITD-349 at doses of 12.5 and 50 mg/kg resulted in 0.9- and 3.4-log CFU reduction in lung tissue. In an established infection mouse model, after 2 weeks of treatment, the efficacy of NITD-349 is comparable to the first-line TB drug rifampicin and is better than ethambutol. Four weeks of treatment at 100 mg/kg with NITD-349 results in 2.38-log CFU reductions[1].
NITD-349 Preparation Products And Raw materials
Raw materials
Preparation Products
NITD-349 Suppliers
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