GNE 220

Product Name: GNE 220
CAS No.: 1199590-75-4
Chemical Name: GNE 220
Synonyms: GNE 220;5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-;6-Methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12 -hexaene
CBNumber: CB33386483
Molecular Formula: C25H26N8
Formula Weight: 438.52754
MOL File: 1199590-75-4.mol

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GNE 220 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 11.21±0.50(Predicted)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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GNE 220 Chemical Properties,Usage,Production

Uses

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.

IC 50

MAP4K4: 7 nM (IC₅₀); MAP4K5: 9 nM (IC₅₀); MAP4K6: 1.1 μM (IC₅₀)

References

[1] Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30. DOI:10.1038/nature14323

GNE 220 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE 220 Suppliers

China 11 United States 3 Global 14

Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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TargetMol Chemicals Inc.

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Nanjing Shizhou Biology Technology Co.,Ltd

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Biosynth Biological Technology (Suzhou) Co Ltd

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
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1199590-75-4, GNE 220Related Search:

GNE 220

5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-

6-Methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12 -hexaene

1199590-75-4

C25H26N8