7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE

Product Name: 7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE
CAS No.: 55580-08-0
Chemical Name: 7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE
Synonyms: 7-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H);7-bromo-3,4-dihydro-2h-1-benzoxepin-5-one;7-BROMO-3,4-DIHYDRO-1-BENZOXEPIN-5(2H)-ONE;7-BROMO-3,4-DIHYDROBENZO[B]OXEPIN-5(2H)-ONE;7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE;1-Benzoxepin-5(2H)-one, 7-bromo-3,4-dihydro-;7-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one;JR-8190, 7-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one, 97%;7-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one 7-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one
CBNumber: CB3345540
Molecular Formula: C10H9BrO2
Formula Weight: 241.08
MOL File: 55580-08-0.mol

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7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE Property

Boiling point:: 104-109 °C(Press: 0.3 Torr)
Density: 1.528±0.06 g/cm3(Predicted)
storage temp.: 2-8°C

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Safety

Risk Statements: 52
RIDADR: UN 3082 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H411Toxic to aquatic life with long lasting effects
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00219
Product name: 7-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one
Purity: Aldrich
Packaging: 1g
Price: $497
Updated: 2025/07/31

Matrix Scientific

Product number: 070629
Product name: 7-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one
Purity: 95%
Packaging: 1g
Price: $530
Updated: 2021/12/16

Matrix Scientific

Product number: 070629
Product name: 7-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one
Purity: 95%
Packaging: 5g
Price: $2285
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003688
Product name: 7-BROMO-3,4-DIHYDROBENZO[B]OXEPIN-5(2H)-ONE
Purity: 95.00%
Packaging: 5G
Price: $4204.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003688
Product name: 7-BROMO-3,4-DIHYDROBENZO[B]OXEPIN-5(2H)-ONE
Purity: 95.00%
Packaging: 10G
Price: $5647.95
Updated: 2021/12/16

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7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE Chemical Properties,Usage,Production

Synthesis

1189816-63-4

55580-08-0

Step H2: 1-[5-Bromo-2-(2-bromoethoxy)phenyl]ethanone (9.0 g, 28.0 mmol) was dissolved in THF (175 mL) and cooled to 0 °C. Under stirring, sodium hydride (0.805 g, 33.5 mmol) was slowly added. The reaction mixture was carefully heated to reflux and maintained at reflux for 20 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 2 M HCl (50 mL). The mixture was transferred to a partition funnel and extracted by adding brine (300 mL) and EtOAc (250 mL). The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent gradient of 10-30% EtOAc/hexane. The pure grades were collected and concentrated under reduced pressure to afford 7-bromo-3,4-dihydro-2H-benzo[B]oxepan-5-one (5.41 g, 22.4 mmol, 80% yield) as a colorless oil.LCMS (M + H)+ = 242.95.1H NMR (500 MHz, CDCl3) δ 7.91-7.85 (m, 1H), 7.54-7.48 (m, 1H), 7.91-7.85 (m, 1H). 7.54-7.48 (m, 1H), 6.98 (d, J = 8.5 Hz, 1H), 4.25 (t, J = 6.6 Hz, 2H), 2.91 (t, J = 6.9 Hz, 2H), 2.23 (quin, J = 6.8 Hz, 2H).

References

[1] Patent: WO2012/162330, 2012, A1. Location in patent: Page/Page column 41-42
[2] Patent: US2009/247567, 2009, A1. Location in patent: Page/Page column 183
[3] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 144-145
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 627 - 640

7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONE Suppliers

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55580-08-0, 7-BROMO-3,4-DIHYDRO-2H-BENZO[B]OXEPIN-5-ONERelated Search:

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