ANTALARMIN HYDROCHLORIDE

Product Name: ANTALARMIN HYDROCHLORIDE
CAS No.: 220953-69-5
Chemical Name: ANTALARMIN HYDROCHLORIDE
Synonyms: Antalarmin hydrochlo;ANTALARMIN HYDROCHLORIDE;N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride;N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
CBNumber: CB3352845
Molecular Formula: C24H35ClN4
Formula Weight: 415.02
MOL File: 220953-69-5.mol

More

Less

ANTALARMIN HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: DMSO: ~24 mg/mL, soluble
form: solid
color: off-white
InChI: InChI=1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChIKey: CGDGXEDXEXACKQ-UHFFFAOYSA-N
SMILES: CC1=C(C2C(=NC(C)=NC=2N1C1C(=CC(C)=CC=1C)C)N(CC)CCCC)C.Cl

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8727
Product name: Antalarmin hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $277.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: A8727
Product name: Antalarmin hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $902.5
Updated: 2025/07/31

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $326
Updated: 2024/03/01

More

Less

ANTALARMIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (K_i = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.

Uses

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

storage

Desiccate at +4°C

References

[1] E L WEBSTER. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.[J]. Endocrinology, 1996, 137 12: 5747-5750. DOI: 10.1210/endo.137.12.8940412
[2] T DEAK. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.[J]. Endocrinology, 1999, 140 1: 79-86. DOI: 10.1210/endo.140.1.6415
[3] HESHAM FAHMY. The “homeostasis hormone” and its CRF? receptor. From structure to function.[J]. Hormones-International Journal of Endocrinology and Metabolism, 2012, 11 3: 254-271. DOI: 10.14310/horm.2002.1355

ANTALARMIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ANTALARMIN HYDROCHLORIDE Suppliers

China 49 India 1 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 61

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2958
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4795
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2962
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9531
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

220953-69-5, ANTALARMIN HYDROCHLORIDERelated Search:

ANTALARMIN HYDROCHLORIDE

N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride

Antalarmin hydrochlo

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)

N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

220953-69-5

C24H34N4HCl