ANTALARMIN HYDROCHLORIDE

Product Name: ANTALARMIN HYDROCHLORIDE
CAS No.: 220953-69-5
Chemical Name: ANTALARMIN HYDROCHLORIDE
Synonyms: Antalarmin hydrochlo;ANTALARMIN HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride;N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
CBNumber: CB3352845
Molecular Formula: C24H35ClN4
Formula Weight: 415.02
MOL File: 220953-69-5.mol

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ANTALARMIN HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: DMSO: ~24 mg/mL, soluble
form: solid
color: off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8727
Product name: Antalarmin hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $270
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8727
Product name: Antalarmin hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $924
Updated: 2024/03/01

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 15147
Product name: Antalarmin (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $326
Updated: 2024/03/01

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ANTALARMIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (K_i = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.

Uses

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

storage

Desiccate at +4°C

ANTALARMIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTALARMIN HYDROCHLORIDE Suppliers

China 21 India 1 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 33

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220953-69-5, ANTALARMIN HYDROCHLORIDERelated Search:

ANTALARMIN HYDROCHLORIDE

N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride

Antalarmin hydrochlo

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)

220953-69-5

C24H34N4HCl