4-(PYRIMIDIN-5-YL)BENZALDEHYDE

Product Name: 4-(PYRIMIDIN-5-YL)BENZALDEHYDE
CAS No.: 198084-12-7
Chemical Name: 4-(PYRIMIDIN-5-YL)BENZALDEHYDE
Synonyms: AKOS BAR-0648;5-(4-FORMYLPHENYL)PYRIMIDINE;4-(5-PYRIMIDINYL)BENZALDEHYDE;4-(PYRIMIDIN-5-YL)BENZALDEHYDE;Benzaldehyde, 4-(5-pyrimidinyl)-;4-PYRIMIDIN-5-YL-BENZALDEHYDE, 95+%;4-(2-Chloropyrimidin-5-yl)benzaldehyde;5-(4-Formylphenyl)pyrimidine;4-(2-(Dimethylamino)pyrimidin-5-yl)benzaldehyde;4-(PYRIMIDIN-5-YL)BENZALDEHYDE ISO 9001：2015 REACH
CBNumber: CB3353110
Molecular Formula: C11H8N2O
Formula Weight: 184.19
MOL File: 198084-12-7.mol

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4-(PYRIMIDIN-5-YL)BENZALDEHYDE Property

Melting point:: 145-149 °C (lit.)
Boiling point:: 369.1±35.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
pka: 1.52±0.10(Predicted)
form: solid
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C11H8N2O/c14-7-9-1-3-10(4-2-9)11-5-12-8-13-6-11/h1-8H
InChIKey: BXNXTOLXLPQMHS-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(C2=CN=CN=C2)C=C1
CAS DataBase Reference: 198084-12-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 647136
Product name: 5-(4-Formylphenyl)pyrimidine
Purity: 97%
Packaging: 1g
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: 647136
Product name: 5-(4-Formylphenyl)pyrimidine
Purity: 97%
Packaging: 5g
Price: $414
Updated: 2023/06/20

TRC

Product number: P997403
Product name: 4-(Pyrimidin-5-yl)benzaldehyde
Packaging: 25mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003024
Product name: 4-PYRIMIDIN-5-YL-BENZALDEHYDE
Purity: 95.00%
Packaging: 1G
Price: $148.05
Updated: 2021/12/16

Matrix Scientific

Product number: 071853
Product name: 4-Pyrimidin-5-yl-benzaldehyde
Purity: 95+%
Packaging: 1g
Price: $162
Updated: 2021/12/16

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4-(PYRIMIDIN-5-YL)BENZALDEHYDE Chemical Properties,Usage,Production

Uses

4-(Pyrimidin-5-yl)benzaldehyde is a useful reactant and reagent in organic reactions such as the synthesis of 1,?2-?difluorination of alkenes, and β-?Cyanoacrylamides.

Synthesis

4595-59-9

87199-17-5

198084-12-7

To a stirred solution of 5-bromopyrimidine (1 eq.), 4-formylphenylboronic acid (1.3-3.0 eq.), and sodium carbonate monohydrate (1.3-3.0 eq.) in a mixed solvent of dimethoxyethane/water (4:1, v/v) (concentration of about 0.05-0.2 M) was added tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 0.1 eq.). The reaction mixture was stirred at 90 °C for about 18 h and subsequently quenched with water. The mixture was extracted with dichloromethane (CH2Cl2) according to standard post-treatment steps and the organic layer was dried over anhydrous sodium sulfate (Na2SO4) or anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography or silica gel radial chromatography. According to the above general method, 4-(5-pyrimidinyl)benzaldehyde (162 mg, 99% yield) was obtained from 5-bromopyrimidine (199 mg, 1.25 mmol) and 4-formylphenylboronic acid (469 mg, 3.13 mmol).

References

[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 25; 71
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065

4-(PYRIMIDIN-5-YL)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(PYRIMIDIN-5-YL)BENZALDEHYDE Suppliers

Belgium 1 China 56 Germany 2 India 1 Russia 1 Switzerland 1 United Kingdom 5 United States 16 Global 83

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View Lastest Price from 4-(PYRIMIDIN-5-YL)BENZALDEHYDE manufacturers

Dideu Industries Group Limited

Product: 4-(PYRIMIDIN-5-YL)BENZALDEHYDE 198084-12-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-09

198084-12-7, 4-(PYRIMIDIN-5-YL)BENZALDEHYDERelated Search:

4-(PYRIMIDIN-5-YL)BENZALDEHYDE 3-PYRIMIDIN-5-YLBENZALDEHYDE 4-(Pyrimidin-5-yl)benzoic acid 4-(2-AMINOPYRIMIDIN-5-YL)BENZOIC ACID 4-PYRIMIDIN-5-YL-BENZOIC ACID ETHYL ESTER 4-(4-(Trifluoromethyl)pyrimidin-2-yl)benzaldehyde 2-FLUORO-4-(PYRIMIDIN-2-YL)BENZALDEHYDE 4-(PYRIMIDIN-4-YL)BENZALDEHYDE 3-(Pyrimidin-4-yl)benzaldehyde 4-(PYRIMIDIN-2-YL)BENZALDEHYDE 3-(4-(Trifluoromethyl)pyrimidin-2-yl)benzaldehyde,3-(PYRIMIDIN-2-YL)BENZALDEHYDE 4-Chloro-3-(6-chloro-pyrimidin-4-yl)-benzaldehyde 3-(2-Amino[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)benzaldehyde 2-(2-Chloro-pyrimidin-4-yl)-benzaldehyde 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde 4-(6-Chloro-pyrimidin-4-yl)-benzaldehyde 3-(6-Chloro-pyrimidin-4-yl)-benzaldehyde 4-(2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)benzaldehyde

4-(PYRIMIDIN-5-YL)BENZALDEHYDE

5-(4-FORMYLPHENYL)PYRIMIDINE

4-(5-PYRIMIDINYL)BENZALDEHYDE

AKOS BAR-0648

4-(2-(Dimethylamino)pyrimidin-5-yl)benzaldehyde

4-(2-Chloropyrimidin-5-yl)benzaldehyde

4-PYRIMIDIN-5-YL-BENZALDEHYDE, 95+%

Benzaldehyde, 4-(5-pyrimidinyl)-

4-(PYRIMIDIN-5-YL)BENZALDEHYDE ISO 9001：2015 REACH

5-<WBR>(4-<WBR>Formylphenyl)<WBR>pyrimidine

198084-12-7