HVRLZEKDTUEKQH-NEGCSKJWSA-N
- Product Name
- HVRLZEKDTUEKQH-NEGCSKJWSA-N
- CAS No.
- 1331635-21-2
- Chemical Name
- HVRLZEKDTUEKQH-NEGCSKJWSA-N
- Synonyms
- HVRLZEKDTUEKQH-NEGCSKJWSA-N;[2H3]- Olopatadine Hydrochloride;2-[(11Z)-11-[3-[methyl(trideuteriomethyl)amino]propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid
- CBNumber
- CB33564603
- Molecular Formula
- C21H21ClD3NO3
- Formula Weight
- 376.891645334
- MOL File
- 1331635-21-2.mol
HVRLZEKDTUEKQH-NEGCSKJWSA-N Property
- storage temp.
- Store at -20°C
- solubility
- Methanol: Slightly soluble,
- form
- A solid
- Water Solubility
- Water: Slightly soluble
N-Bromosuccinimide Price
- Product number
- O575002
- Product name
- Olopatadine-d3Hydrochloride
- Packaging
- 1mg
- Price
- $175
- Updated
- 2021/12/16
HVRLZEKDTUEKQH-NEGCSKJWSA-N Chemical Properties,Usage,Production
Uses
Labelled Olopatadine. Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.
Biological Activity
Olopatadine-d3 is intended for use as an internal standard for the quantification of olopatadine by GC- or LC-MS. Olopatadine is a histamine H1 receptor antagonist (Ki =41 nM).1 It is 1,059- and 4,177-fold selective for histamine H1 over H2 and H3 receptors, respectively. Olopatadine inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human trabecular meshwork (TM3) cells (IC50s = 9.5, 19, and 39.9 nM, respectively). In vivo, olopatadine inhibits passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50 = 30 μg/kg).2 Formulations containing olopatadine have been used in the treatment of allergic rhinitis and conjunctivitis, as well as in the treatment of itch in patients with well-controlled urticaria.
References
1.Sharif, N.A., Xu, S.X., and Yanni, J.M.Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitisJ. Ocul. Pharmacol. Ther.12(4)401-407(1996) 2.Ohshima, E., Otaki, S., Sato, H., et al.Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivativesJ. Med. Chem.35(11)2074-2084(1992)
HVRLZEKDTUEKQH-NEGCSKJWSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
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