ChemicalBook > CAS DataBase List > ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
- Product Name
- ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
- CAS No.
- 307519-88-6
- Chemical Name
- ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
- Synonyms
- NMDI14;NMDI14 >=97% (HPLC);inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14;ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester
- CBNumber
- CB33589260
- Molecular Formula
- C21H25N3O4S
- Formula Weight
- 415.51
- MOL File
- 307519-88-6.mol
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ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Property
- Boiling point:
- 658.8±55.0 °C(Predicted)
- Density
- 1.250±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 25 mg/mL (60.17 mM)
- form
- powder
- pka
- 13.42±0.40(Predicted)
- color
- white to beige
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1538
- Product name
- NMDI14
- Purity
- ≥97% (HPLC)
- Packaging
- 5MG
- Price
- $153
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SML1538
- Product name
- NMDI14
- Purity
- ≥97% (HPLC)
- Packaging
- 25MG
- Price
- $530
- Updated
- 2023/06/20
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ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Chemical Properties,Usage,Production
Uses
NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
- to study its effects on differentiating cardiomyocytes
- to study its effects on zebrafish pdzk1 gene-knockout embryos
- to analyze its effects on the apoptosis of colorectal cancer cells
Biochem/physiol Actions
NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Suppliers
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