FELBAMATE-D4 Property

Melting point:

146-148°C

storage temp. 

-20°C Freezer

solubility 

Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H336May cause drowsiness or dizziness

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

FELBAMATE-D4 Chemical Properties,Usage,Production

Description

Felbamate-d₄ is intended for use as an internal standard for the quantification of felbamate by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABA_A receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors. It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 μM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner. Felbamate is a positive modulator of α₁β₂γ_2S, α₁β₃γ_2S, α₂β₂γ_2S, and α₂β₃γ_2S subunit-containing GABA_A receptors expressed in X. laevis oocytes, with negative modulation of GABA_A receptors containing the subunits α₁β₁, α₁β₃γ_2L, α₄β₁γ_2S, α₄β₃γ_2S, and α₆β₁γ_2S. It inhibits seizures induced by maximal electroshock, pentylenetetrazole , and picrotoxin in mice (ED₅₀s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.

Chemical Properties

White Solid

Uses

Antiepileptic, structurally similar to meprobamate.