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4'-CHLOROACETANILIDE

Product Name
4'-CHLOROACETANILIDE
CAS No.
539-03-7
Chemical Name
4'-CHLOROACETANILIDE
Synonyms
NSC 444;NSC 40563;4-Chloroacetan;PARACETAMOL RC J;4-CHLORACETANILIDE;p-Chloroacetanilid;P-CHLOROACETANILIDE;4-CHLOROACETANILIDE;4'-CHLOROACETANILIDE;ACETAMINOPHENE IMP J
CBNumber
CB3377826
Molecular Formula
C8H8ClNO
Formula Weight
169.61
MOL File
539-03-7.mol
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4'-CHLOROACETANILIDE Property

Melting point:
176-178 °C(lit.)
Boiling point:
333 °C
Density 
1,385 g/cm3
refractive index 
1.5670 (estimate)
Flash point:
333°C
storage temp. 
2-8°C
solubility 
dioxane: 50 mg/mL hot, clear
pka
14.25±0.70(Predicted)
form 
Crystalline Powder
color 
White or grayish-beige
Water Solubility 
Insoluble in water.
Merck 
14,2111
BRN 
509638
CAS DataBase Reference
539-03-7(CAS DataBase Reference)
EPA Substance Registry System
4-Chloroacetanilide (539-03-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AE1001000
TSCA 
Yes
HS Code 
29242990
Hazardous Substances Data
539-03-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001945
Product name
Paracetamol impurity J
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001945
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41480
Product name
4-Chloroacetanilide
Purity
for synthesis
Packaging
50g
Price
$65.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41480
Product name
4-Chloroacetanilide
Purity
for synthesis
Packaging
250g
Price
$299
Updated
2024/03/01
Sigma-Aldrich
Product number
158631
Product name
4′-Chloroacetanilide
Purity
97%
Packaging
5g
Price
$43.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1003100
Product name
Acetaminophen Related Compound J
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1380
Updated
2024/03/01
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4'-CHLOROACETANILIDE Chemical Properties,Usage,Production

Chemical Properties

white or greyish-beige crystalline powder

Uses

4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.

Definition

ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

General Description

4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.

Purification Methods

Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]

4'-CHLOROACETANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-CHLOROACETANILIDE Suppliers

Americas 1 Belgium 3 Canada 2 China 216 Europe 3 Germany 10 India 56 Japan 5 Norway 1 South Korea 1 Switzerland 1 United Kingdom 14 United States 42 Global 355
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Nacalai Tesque Inc.
Tel
--
Fax
--
Email
info.intl@nacalai.co.jp
Country
Japan
ProdList
73
Advantage
58
FUJIFILM Wako Pure Chemical Corporation
Tel
--
Fax
--
Email
ffwk-cservice@fujifilm.com
Country
Japan
ProdList
6222
Advantage
58
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from 4'-CHLOROACETANILIDE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4'-CHLOROACETANILIDE 539-03-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Fengqiang Trading Co., LTD
Product
4'-CHLOROACETANILIDE 539-03-7
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-08-30
Hebei Mojin Biotechnology Co., Ltd
Product
4'-CHLOROACETANILIDE 539-03-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-04

539-03-7, 4'-CHLOROACETANILIDERelated Search:

2-Acetamidophenol ACETAMINOPHEN IMPURITY B 4,4'-Iminodiphenol hydrochloride 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one 4'-Hydroxyacetophenone 3-CHLORO-4-HYDROXYACETANILIDE 2'-Hydroxyacetophenone 4-Acetoxyacetanilide N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE Acetanilide 1-(2,4,6-Trichlorophenyl)-3-amino-pyrazolin-5-one 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide N-(4-Chlorophenyl)-2-chloroacetamide Propanil 4'-Chloro-2'-methylacetoacetanilide 5-Chloroisatin 5-BROMO-4'-CHLOROSALICYLANILIDE 3',5'-BIS(TRIFLUOROMETHYL)-2-CHLOROACETANILIDE

  • ACETIC ACID 4-CHLOROANILIDE
  • ACETAMINOPHEN IMPURITY J
  • ACETAMINOPHENE IMP J
  • 4'-CHLOROACETANILIDE
  • 4-CHLOROACETANILIDE
  • 4-CHLORACETANILIDE
  • LABOTEST-BB LT00792311
  • P-CHLOROACETANILIDE
  • N-(4-CHLORO-PHENYL)-ACETAMIDE
  • P-ChloroAcetanilide-(AceticAcid-4-Chloroanilide,4-ChloroAcetanilide)
  • P-ChloroAcetanilideGr-(AceticAcid-4-Chloroanilide,4-ChloroAcetanilide)
  • P-ChloroAcetanilideGr
  • 4''-CHLOROACETANILIDE, 98+%
  • p-CHLOROACETANILIDE extrapure AR
  • 4'-Chloroacetanilide,97%
  • 4′-Chloroacetanilide,Acetic acid 4-chloroanilide
  • NSC 40563
  • NSC 444
  • p-Chloroacetanilid
  • AcetaMinophen IMpurity J (ParacetaMol IMpurity J)
  • AcetaMinophen Related CoMpound J
  • 4-Chloroacetan
  • Acetaminophen Related Compound J (50 mg) (N-(4-chlorophenyl)acetamide)
  • Paracetamol Impurity-J(EP/BP)
  • 4’-chloro-acetanilid
  • 4-chlorophenylethanamide
  • Acetamide,N-(4-chlorophenyl)-
  • Acetanilide, 4'-chloro-
  • Acetic-4-chloroanilide
  • Acet-p-chloroanilide
  • amide,n(4-chlorophenyl)-aceticaci
  • ethanamide,4-chlorophenyl-
  • n-(4-chlorophenyl)-acetamid
  • N-(p-Chlorophenyl)acetamide
  • N-Acetyl-4-chloroaniline
  • N-Acetyl-p-chloroaniline
  • p-Chloroacetoanilide
  • Acetaminophen impurity 10
  • 4-Chloroacetanilide (Acetaminophen RCJ)
  • Paracetamol EP Impurity J
  • Paracetamol Impurity 10(Paracetamol EP Impurity J)
  • 4’-CHLOROACETANILIDE(Acetaminophen Related Compound J)
  • paracetamol impurity J
  • 4'-Chloroacetanilide &gt
  • N-(4-Chlorophenyl)acetamide (4-Chlo
  • 4-CHLOROACETANILIDE FOR SYNTHESIS
  • Paracetamol(Acetaminophen) EP Impurity J
  • Paracetamol Impurity-J/4-Chloroacetanilide
  • Parachloroacetanilide
  • 4-Chloroacetanilide/ Paracetamol Impurity-J
  • Acetaminophen impurities1464
  • Acetaminophen EP Impurity J
  • Acetaminophen Related Compound J (R00310)
  • p-Chloroacetanilide, GR 99%+
  • Paracetamol EP Impurity JQ: What is Paracetamol EP Impurity J Q: What is the CAS Number of Paracetamol EP Impurity J Q: What is the storage condition of Paracetamol EP Impurity J Q: What are the applications of Paracetamol EP Impurity J
  • p-Chloroacetanilide extrapure AR, ExiPlus, Multi-Compendial, 99%
  • Acetaminophen Related Compound J (N-(4-chlorophenyl)acetamide) (1003100)
  • Acetaminophen USP Related Compound J