1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester

Product Name: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester
CAS No.: 761446-45-1
Chemical Name: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester
Synonyms: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol;1-Benzylpyrazole-4-boronic acid pinacol ester;1-BENZYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER;1-Benzyl-1H-pyrazole-4-boronic acid picol ester;1-BENZYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER;1-BENZYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER;1-BENZYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER, 95%;1-Benzyl-1H-pyrazol-4-ylboronic acid, pinacol ester;1-benzyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
CBNumber: CB3377967
Molecular Formula: C16H21BN2O2
Formula Weight: 284.16
MOL File: 761446-45-1.mol

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1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester Property

Melting point:: 86-90 °C(lit.)
Boiling point:: 427.9±28.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 1.85±0.10(Predicted)
form: solid
color: white to yellow
Water Solubility: Insoluble
InChIKey: ZVPORPUUZXIPEF-UHFFFAOYSA-N
CAS DataBase Reference: 761446-45-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-23-22
Safety Statements: 22-24/25-37/39-26-36/37/38
WGK Germany: 3
Hazard Note: Irritant
TSCA: No
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 636002
Product name: 1-Benzylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $43
Updated: 2023/06/20

Sigma-Aldrich

Product number: 636002
Product name: 1-Benzylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $99
Updated: 2023/06/20

TCI Chemical

Product number: B4364
Product name: 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B4364
Product name: 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $272
Updated: 2025/07/31

TRC

Product number: B288768
Product name: 1-Benzylpyrazole-4-boronic acid pinacol ester
Packaging: 1g
Price: $75
Updated: 2021/12/16

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1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystals or

Uses

1-Benzylpyrazole-4-boronic acid pinacol ester can be used:

As a model compound in the study of the stability of boronate esters in different alcohols using the LCMS technique.
As a substrate in the study of palladium-catalyzed methylation of heteroaryl boronate esters using iodomethane.
As a substrate in the preparation of bromodifluoromethylthiolated arenes, applicable in the radiosynthesis of [¹⁸F]ArylSCF₃ compounds.

Synthesis

269410-08-4

100-39-0

761446-45-1

GENERAL STEPS: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (3.0 g, 15.5 mmol) was mixed with bromomethylbenzene (3.2 g, 18.7 mmol) in a solution of DMF (30 mL) containing K2CO3 (4.3 g, 31.2 mmol) and stirred at room temperature overnight. After completion of the reaction, the reaction mixture was diluted with EtOAc (50 mL) and H2O (50 mL), the organic layer was separated and washed with brine (50 mL). The organic layer was dried over Na2SO4, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography using PE/EtOAc (5:1) as eluent to afford the target compound 1-benzyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (3.5 g, 12.3 mmol) as a light yellow solid in 79% yield.1H NMR (400 MHz. CDCl3): δ 7.81 (s, 1H), 7.66 (s, 1H), 7.37-7.29 (m, 3H), 7.24-7.22 (m, 2H), 5.30 (s, 2H), 1.29 (s, 12H). lcms (M + H) + 285.

References

[1] Patent: US2018/296543, 2018, A1. Location in patent: Paragraph 0573; 0574; 0600
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 284; 285
[3] Patent: WO2016/124508, 2016, A1. Location in patent: Page/Page column 55
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[5] Patent: WO2014/60395, 2014, A1. Location in patent: Page/Page column 35

1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester Suppliers

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View Lastest Price from 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 761446-45-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 20 tons
Release date: 2025-07-24

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 761446-45-1
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 761446-45-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

761446-45-1, 1-Benzyl-1H-pyrazole-4-boronic acid pinacol esterRelated Search:

Benzyl benzoate Benzyltrimethylammonium chloride Benzyl butyrate Benzyl bromide Benzyl chloride Pinacol Benzyl acetate Benzyl alcohol Benzoyl peroxide Pyrazole N,N-Dimethylbenzylamine Benzylboronic acid 2,2,4-Trimethyl-1,3-pentanediol monoisobutyrate Benzyltriethylammonium chloride DIBENZYLTOLUENE Phenylacetone 1-Methyl-4-pyrazole boronic acid pinacol ester Benzyl

1-BENZYL- 4-PYRAZOLEBORONIC ACID PINACOL ESTER

1-Benzyl-4-pyrazole boronic acid pinacol ester, 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole,97%

1-benzyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyra

1H-Pyrazole, 1-(phenylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

1-(PhenylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, {[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}benzene

1-benzyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1-Benzyl-1H-pyrazole-4-boronic acid pinacol

3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (1-benzyl-1H-pyrazol-4-yl)boronate

1-Benzyl-1H-pyrazole-4-boronic acid pinacol ester 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-BENZYL-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

1-BENZYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER

1-BENZYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE

1-Benzyl-1H-pyrazole-4-boronic acid picol ester

1-Benzyl-1H-pyrazol-4-ylboronic acid, pinacol ester

1-BENZYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER, 95%

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole &gt

2-(1-Benzyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-(Phenylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [P10046]

1-Benzylpyrazole-4-boronic acid pinacol ester

761446-45-1

C16H21BN2O2

API intermediates