ChemicalBook > CAS DataBase List > 2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide

2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide

Product Name
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS No.
925069-34-7
Chemical Name
2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide
Synonyms
PI-273;PI-273 ，E2374;PI-273, 10 mM in DMSO;2-(3-(4-Chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide;2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide;2-({[(4-chlorobenzoyl)amino]carbonothioyl}amino)-4-ethyl-5-methyl-3-thiophenecarboxamide;3-Thiophenecarboxamide, 2-[[[(4-chlorobenzoyl)amino]thioxomethyl]amino]-4-ethyl-5-methyl-;2-({[(4-Chlorophenyl)carbonyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide;PI4K,Inhibitor,PI4 kinases,PI 273,PI273,Apoptosis,inhibit,Phosphatidylinositol 4 kinases,PI-273
CBNumber
CB33806116
Molecular Formula
C16H16ClN3O2S2
Formula Weight
381.9
MOL File
925069-34-7.mol
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2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Property

Density 
1.425±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 6.25 mg/mL (16.37 mM)
form 
Solid
pka
8.09±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0027993
Product name
PI-273
Purity
>98.0%
Packaging
1mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0027993
Product name
PI-273
Purity
>98.0%
Packaging
5mg
Price
$160
Updated
2021/12/16
Axon Medchem
Product number
Axon3034
Product name
PI-273
Purity
98%
Packaging
2x5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0027993
Product name
PI-273
Purity
>98.0%
Packaging
10mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-0027993
Product name
PI-273
Purity
>98.0%
Packaging
25mg
Price
$550
Updated
2021/12/16
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2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Chemical Properties,Usage,Production

Uses

PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis[1].

in vivo

PI-273 (intraperitoneal injection; 25 mg/kg/day; 15 days) profoundly suppresses the tumor volume and weight in the MCF-7 xenografts[1].
PI-273 (0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically); 0.08-5 hours) has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%[1].

Animal Model:Eight-week-old male BALB/c nude mice with MCF-7 cell[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection; daily; 15 days
Result:Suppressed the tumor volume and weight in the MCF-7 xenografts.
Animal Model:Male Sprague-Dawley (SD) rats[1]
Dosage:0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically) (Pharmacokinetic Study)
Administration:Intravenously or intragastrically; 0.08, 0.16, 0.33, 0.67, 1, 1.5, 2, 3 and 5 hours
Result:Has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%.

IC 50

PI4KIIα: 0.47 μM (IC50)

References

[1] Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266. DOI:10.1158/0008-5472.CAN-17-0484

2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide Suppliers

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925069-34-7, 2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamideRelated Search:


  • 2-[(4-chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide
  • 2-({[(4-chlorobenzoyl)amino]carbonothioyl}amino)-4-ethyl-5-methyl-3-thiophenecarboxamide
  • PI-273
  • 3-Thiophenecarboxamide, 2-[[[(4-chlorobenzoyl)amino]thioxomethyl]amino]-4-ethyl-5-methyl-
  • 2-(3-(4-Chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide
  • PI4K,Inhibitor,PI4 kinases,PI 273,PI273,Apoptosis,inhibit,Phosphatidylinositol 4 kinases,PI-273
  • PI-273, 10 mM in DMSO
  • 2-({[(4-Chlorophenyl)carbonyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide
  • PI-273 ，E2374
  • 925069-34-7