3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE
- Product Name
- 3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE
- CAS No.
- 1173023-36-3
- Chemical Name
- 3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE
- Synonyms
- L-745,870 HYDROCHLORIDE;L-745870 hydrochloride, 10 mM in DMSO;3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE;L745870,dopamine,L 745870,inhibit,penetration,receptor,Human,brain,Inhibitor,neuroleptics,L-745870,Dopamine Receptor,L 745870 hydrochloride,L745870 hydrochloride
- CBNumber
- CB3387546
- Molecular Formula
- C18H20Cl2N4
- Formula Weight
- 363.28
- MOL File
- Mol file
3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE Property
- storage temp.
- Store at -20°C
- solubility
- H2O: 0.2 mg/mL
- form
- solid
- color
- white
- Water Solubility
- H2O: 0.2mg/mL
ethanol: 1.4mg/mL
0.1 M HCl: 5.5mg/mL
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L131
- Product name
- L-745,870 hydrochloride
- Packaging
- 5mg
- Price
- $329
- Updated
- 2025/07/31
- Product number
- L131
- Product name
- L-745,870 hydrochloride
- Packaging
- 25mg
- Price
- $660.8
- Updated
- 2025/07/31
- Product number
- INB0001067
- Product name
- L-745,870 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $817.56
- Updated
- 2021/12/16
- Product number
- INB0001067
- Product name
- L-745,870 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $1428.62
- Updated
- 2021/12/16
- Product number
- CS-0109248
- Product name
- L-745,870 hydrochloride
- Purity
- 99.88%
- Packaging
- 50mg
- Price
- $420
- Updated
- 2021/12/16
3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors[1][2][3].
Biological Activity
Selective D4 dopamine receptor antagonist.
in vivo
L-745870 has good pharmacokinetic properties (20-60% oral bioavailability and plasma t1/2 2.1-2.8 hours) in both rat and monkey, and excellent brain penetration with high brain to plasma ratios in rat[1].
Following oral administration to squirrel monkeys, L745870 (10 mg/kg p.o.) induces mild sedation and extrapyramidal motor symptoms, notably bradykinesia, became apparent at 30 mg/kg. Lower doses of L-745870 has no observable behavioural effects in monkeys[1].
IC 50
Human D4 Receptor: 4.3 nM (Ki); D2 Receptor: 960 nM (Ki); D3 Receptor: 2300 mM (Ki)
References
[1] Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8. DOI:10.1016/s0165-6147(97)01066-3
[2] Patel S, et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47. PMID:9353380
[3] Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2. DOI:10.1021/jm9600712
3-([4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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