METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

Product Name: METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
CAS No.: 36622-40-9
Chemical Name: METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
Synonyms: (-)-D 600;(-)-Gallopamil;(-)-Methoxyverapamil;Gallopamil, ( ) ,Gallopamil, ();(-)-METHOXYVERAPAMIL HYDROCHLORIDE;METHOXY-(-)-VERAPAMIL HYDROCHLORIDE;(-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-, (αS)-
CBNumber: CB3393460
Molecular Formula: C28H40N2O5
Formula Weight: 484.63
MOL File: 36622-40-9.mol

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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Property

Boiling point:: 605.9±55.0 °C(Predicted)
Density: 1.068±0.06 g/cm3(Predicted)
solubility: H₂O: soluble
pka: 8.96±0.50(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2].

References

[1] Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. DOI:10.1161/hh2001.098983
[2] Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. DOI:10.1111/j.1469-7793.1999.0315m.x

METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Suppliers

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36622-40-9, METHOXY-(-)-VERAPAMIL HYDROCHLORIDERelated Search:

5-TERT-BUTYLPYROGALLOL 3,4,5-Trimethoxyphenylacetonitrile 3-tert-Butylphenol 4-HYDROXY-3-METHOXYPHENYLACETONITRILE R(+)-VERAPAMIL HYDROCHLORIDE (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile (3,4-DIHYDROXYPHENYL)ACETONITRILE (3-Methoxyphenyl)acetonitrile (3,4-Dimethoxyphenyl)acetonitrile METHOXY-(-)-VERAPAMIL HYDROCHLORIDE 3-Methylbutanenitrile (+/-)-Verapamil hydrochloride 2-PHENYLBUTYRONITRILE 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 4-Methoxybenzyl cyanide Trimethylacetonitrile 2-(4-Methoxyphenyl)-2-methylpropanenitrile METHOXYVERAPAMIL HYDROCHLORIDE

(-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE

(-)-METHOXYVERAPAMIL HYDROCHLORIDE

METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

(-)-D 600

(-)-Gallopamil

(-)-Methoxyverapamil

Gallopamil, ( ) ,Gallopamil, ()

Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-, (αS)-

36622-40-9

C28H40N2O5HCl

BioChemical

Cell Biology

Calcium Channel Modulators

Cell Signaling and Neuroscience

Ion Channels

Voltage-gated Ion Channels

Calcium Channel Modulators

Verapamil

Voltage-gated Ion Channels