N-Acetyl-L-methionine Property

Melting point:

103-106 °C(lit.)

alpha 

-20 º (c=4 H2O)

Boiling point:

235 °C(Press: 12 Torr)

Density 

1.2684 (rough estimate)

refractive index 

-21 ° (C=1, H2O)

storage temp. 

Sealed in dry,Room Temperature

solubility 

methanol: soluble100mg/mL, clear, colorless

pka

3.50±0.10(Predicted)

form 

Solid

color 

White to Off-White

optical activity

[α]20/D -21.0±1.0°, c = 1% in H2O

Merck 

14,96

BRN 

1725552

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

XUYPXLNMDZIRQH-LURJTMIESA-N

LogP

-0.885 (est)

CAS DataBase Reference

65-82-7(CAS DataBase Reference)

NIST Chemistry Reference

N-acetylmethionine(65-82-7)

EPA Substance Registry System

L-Methionine, N-acetyl- (65-82-7)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

RTECS 

PD0480000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29309070

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

N-Acetyl-L-methionine Chemical Properties,Usage,Production

Identification Test

Take a sample of 250mg, get it dissolved it in 2.5ml isopropyl alcohol and get it diluted with water to 25ml. Take this liquid of 10ml and get it diluted with water to 100m1. Then take the liquid of 0.5,30 and 50μ1 after two dilutions. Drop it at the place with a distance of 2cm from the bottom edge of the thin-layer chromatographic plate. The plate is coated with silica gel (Namely, 20cm * 20cm Brinkman silica gel of 60.250nm, or the equivalent). In a sealed and balanced thin-layered chromatography expansion tank, The chromatography was splayed out by 10cm, and the developer was composed of n-butanol and the mixture of acetic acid and water in the proportion 75：20=20.

Dry the plate overnight. Then spray the chromatography plate with a new iodoplatinate solution mixed with 10 percent chloroplatinic acid of 3ml, water of 97ml and 6 percent potassium iodide solution of 100ml. The sample shall be formed - a separate color spot with a Rf value of 0.67~0.1

Content Analysis

Weigh accurately about 250mg sample and put it in a flask with glass stopper. Add 100ml water, 5g dipotassium hydrogen phosphate, 2g potassium dihydrogen phosphate and 2g potassium iodide. Get it fully mixed and dissolved, plus 0. 1mol/L iodine solution of 50.0m1. Then stopper it and blend it. Leave it stand for 30 minutes and titrate excess iodine with 0.1mol / L sodium thiosulfate. Meanwhile conduct blank titration experiment. Iodine solution per Ml 0.1mol/L equals to this product (C7H13NO3S) 9.563mg.

Toxicity Grade

Safe for food(FDA，§172．372，2000).

Acute Toxicity

Vein - mouse LD50: 435 mg / kg

Use Quantity

Account for 3.1% of the total protein content in food (Calculated by free L- methionine).
It shall not be used for infant food and food containing adding nitrite / nitrate (FDA, 172.3722000).

Chemical Properties

white crystals

Uses

N-Acetyl-L-methionine (CAS# 65-82-7) has been useful in the study of metabolic phenotypes of standard and cold-?stored platelets.

Definition

ChEBI: An L-methionine derivative that is L-methionine in which one of the amine hydrogens is substituted by an acetyl group.

Safety Profile

Poison by intravenous route. When heated to decomposition emits toxic fumes of NOX,.

Purification Methods

Crystallise N-acetyl-L-methionine from Me2CO, H2O or EtOAc. Dry it in a vacuum over P2O5. Its solubility at 25o in H2O is 30.7%, and in Me2CO it is 29.5%. [Mitzi & Schueter Biochim Biophys Acta 27 168 1958, Birnbaum et al. J Biol Chem 194 455 1952, Beilstein 4 IV 3206.]