ChemicalBook > CAS DataBase List > MC-VC-PAB-MMAF
MC-VC-PAB-MMAF
- Product Name
- MC-VC-PAB-MMAF
- CAS No.
- 863971-17-9
- Chemical Name
- MC-VC-PAB-MMAF
- Synonyms
- Mc-VC-MMAF;MC-VC-PAB-MMAF;Val-Cit-PAB-MMAF;Benzoicacid,3,4,7-tris(phenylmethoxy)-;2-[[3-[1-[4-[[2-[[2-[[4-[[5-(Carbamoylamino)-2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methoxycarbonyl;(2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methoxycarbonyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl;L-Phenylalanine, N-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-;(2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methoxycarbonyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
- CBNumber
- CB33948919
- Molecular Formula
- C68H103N11O16
- Formula Weight
- 1330.61
- MOL File
- 863971-17-9.mol
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MC-VC-PAB-MMAF Property
- Boiling point:
- 1377.2±65.0 °C(Predicted)
- Density
- 1.213±0.06 g/cm3(Predicted)
- pka
- 3.56±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- FLQSNYUAYBTJGF-VOTJHACZNA-N
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0064265
- Product name
- MC-Val-Cit-PAB-MMAF
- Purity
- 98.05%
- Packaging
- 1mg
- Price
- $290
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0064265
- Product name
- MC-Val-Cit-PAB-MMAF
- Purity
- 98.05%
- Packaging
- 5mg
- Price
- $600
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0064265
- Product name
- MC-Val-Cit-PAB-MMAF
- Purity
- 98.05%
- Packaging
- 10mg
- Price
- $950
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0064265
- Product name
- MC-Val-Cit-PAB-MMAF
- Purity
- 98.05%
- Packaging
- 25mg
- Price
- $1650
- Updated
- 2021/12/16
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MC-VC-PAB-MMAF Chemical Properties,Usage,Production
Uses
MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity[1].
IC 50
Auristatin
References
[1] Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. DOI:10.1158/1535-7163.MCT-17-1215
MC-VC-PAB-MMAF Preparation Products And Raw materials
Raw materials
Preparation Products
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MC-VC-PAB-MMAF Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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- +1-781-999-5354;
- support@targetmol.com
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- United States
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- tp@aladdinsci.com
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