tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate

Product Name: tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
CAS No.: 1698027-20-1
Chemical Name: tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
Synonyms: 1588-A4;ARS-1620 Intermediate;1588-A-4,1588A4,1588 A4;tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(7-bromo-6-chloro-8-fluoro-4-quinazolinyl)-, 1,1-dimethylethyl ester
CBNumber: CB33959797
Molecular Formula: C17H19BrClFN4O2
Formula Weight: 445.71
MOL File: 1698027-20-1.mol

More

Less

tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Property

Boiling point:: 534.9±50.0 °C(Predicted)
Density: 1.521±0.06 g/cm3(Predicted)
solubility: DMSO: Slightly soluble: 0.1-1 mg/ml
pka: 10.06±0.70(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Description

1588-A4 is a synthetic intermediate that has been used in the synthesis of the K-RasG12C inhibitor ARS1620 (Item No. 27915).1 WARNING This product is not for human or veterinary use.

References

[1] MATTHEW R JANES. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.[J]. Cell, 2018, 172 3: 578-589.e17. DOI: 10.1016/j.cell.2018.01.006

tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate Suppliers

China 54 United States 2 Global 56

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 2999
Advantage: 62

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3764
Advantage: 58

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai Uchem Inc.

Tel: 15618758386; 15618758386
Fax: QQ:3004479444
Email: sales3@myuchem.com
Country: China
ProdList: 1999
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

1698027-20-1, tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylateRelated Search:

1588-A4

tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-(7-bromo-6-chloro-8-fluoro-4-quinazolinyl)-, 1,1-dimethylethyl ester

ARS-1620 Intermediate

1588-A-4,1588A4,1588 A4

1698027-20-1

C17H19BrClFN4O2