Uses
ChemicalBook > CAS DataBase List > 3,4-DIFLUOROBENZENESULFONAMIDE

3,4-DIFLUOROBENZENESULFONAMIDE

Uses
Product Name
3,4-DIFLUOROBENZENESULFONAMIDE
CAS No.
108966-71-8
Chemical Name
3,4-DIFLUOROBENZENESULFONAMIDE
Synonyms
BUTTPARK 21\07-17;3,4-DIFLUOROBENZENESULFONAMIDE;3,4-DIFLUOROBENZENESULPHONAMIDE;Benzenesulfonamide, 3,4-difluoro-;3,4-Difluorobenzenesulfonamide>Benzenesulfonamide, 3,4-difluoro- (9CI);3,4-DIFLUOROBENZENESULFONAMIDE ISO 9001：2015 REACH
CBNumber
CB3397332
Molecular Formula
C6H5F2NO2S
Formula Weight
193.17
MOL File
108966-71-8.mol
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3,4-DIFLUOROBENZENESULFONAMIDE Property

Melting point:
89-93 °C (lit.)
Boiling point:
314.4±52.0 °C(Predicted)
Density 
1.523±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
9.79±0.60(Predicted)
color 
White to Almost white
CAS DataBase Reference
108966-71-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559571
Product name
3,4-Difluorobenzenesulfonamide
Purity
97%
Packaging
1g
Price
$54.1
Updated
2023/06/20
TCI Chemical
Product number
D4892
Product name
3,4-Difluorobenzenesulfonamide
Purity
>98.0%(GC)
Packaging
1g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
D4892
Product name
3,4-Difluorobenzenesulfonamide
Purity
>98.0%(GC)
Packaging
5g
Price
$92
Updated
2025/07/31
TRC
Product number
D451853
Product name
3,4-Difluorobenzenesulfonamide
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
005179
Product name
3,4-Difluorobenzenesulfonamide
Purity
98%
Packaging
5g
Price
$51
Updated
2021/12/16
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3,4-DIFLUOROBENZENESULFONAMIDE Chemical Properties,Usage,Production

Uses

3,4-Difluorobenzenesulfonamide is an amide derivative that can be used as an organic intermediate.

Synthesis

145758-05-0

108966-71-8

Step 2: Synthesis of 3,4-difluorobenzenesulfonamide (a-3); A solution of anhydrous dichloromethane (1.5 L) of crude 3,4-difluorobenzene-1-sulfonyl chloride (a-2) (200 g, 0.92 mol) was vented with ammonia (NH3) at -30 °C. After 10 minutes of venting, formation of a white viscous substance was observed. After 30 minutes of reaction, thin layer chromatography (TLC) analysis (unfolding agent ratio of ethyl acetate: petroleum ether = 1:2) showed completion of the reaction. Subsequently, the reaction mixture was concentrated under vacuum to give the crude product. The crude product was purified by column chromatography (eluent gradient of ethyl acetate: petroleum ether = 1:5 to 1:2, and finally pure ethyl acetate) to afford the pure 3,4-difluorobenzenesulfonamide (a-3) (170 g, yield ca. 92.8%) as a white solid, which could be used in the subsequent reaction without further purification.1H NMR (400 MHz, DMSO-d6): δ 7.82 (t , J=Hz, 1H), 7.67 (m, 2H), 7.52 (s, 1H).

References

[1] Patent: WO2008/75152, 2008, A1. Location in patent: Page/Page column 33; 34
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 19, p. 3975 - 3984
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 10, p. 3098 - 3105

3,4-DIFLUOROBENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-DIFLUOROBENZENESULFONAMIDE Suppliers

Americas 1 China 90 Europe 2 Germany 3 India 4 Italy 1 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 12 United States 17 Global 134
Alfa Aesar
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View Lastest Price from 3,4-DIFLUOROBENZENESULFONAMIDE manufacturers

Career Henan Chemical Co
Product
3,4-DIFLUOROBENZENESULFONAMIDE 108966-71-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

108966-71-8, 3,4-DIFLUOROBENZENESULFONAMIDERelated Search:

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  • 3,4-DIFLUOROBENZENESULFONAMIDE
  • 3,4-DIFLUOROBENZENESULPHONAMIDE
  • BUTTPARK 21\07-17
  • Benzenesulfonamide, 3,4-difluoro- (9CI)
  • 3,4-Difluorobenzenesulfonamide&gt
  • Benzenesulfonamide, 3,4-difluoro-
  • 3,4-DIFLUOROBENZENESULFONAMIDE ISO 9001：2015 REACH
  • 108966-71-8
  • F2C6H3SO2NH2
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  • SULFONAMIDE
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