TONABERSAT
- Product Name
- TONABERSAT
- CAS No.
- 175013-84-0
- Chemical Name
- TONABERSAT
- Synonyms
- SB 22045;SB 220453;TONABERSAT;SB 220453;SB220453;Tonabersat [ban, inn];Tonabersat (SB-220453);Tonabersat >=98% (HPLC);SB-220453;SB 220453;SB220453;N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-diMethylchroMan-4-yl)-3-chloro-4-fluorobenzaMide;2H-Benzo(B)pyran-3-ol, 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-
- CBNumber
- CB3406968
- Molecular Formula
- C20H19ClFNO4
- Formula Weight
- 391.82
- MOL File
- 175013-84-0.mol
TONABERSAT Property
- Boiling point:
- 554.5±50.0 °C(Predicted)
- Density
- 1.38
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- pka
- 11.86±0.60(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -100 to -110°, c = 1 in methanol
Safety
- RIDADR
- UN 3077 9 / PGIII
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
N-Bromosuccinimide Price
- Product number
- SML1354
- Product name
- Tonabersat
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $185
- Updated
- 2023/06/20
- Product number
- SML1354
- Product name
- Tonabersat
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $704
- Updated
- 2023/06/20
- Product number
- 19796
- Product name
- Tonabersat
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19796
- Product name
- Tonabersat
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 19796
- Product name
- Tonabersat
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
TONABERSAT Chemical Properties,Usage,Production
Uses
It is a cholinesterase inhibitor for treating and preventing migraine. An antimigraine agent.
Biological Activity
migraine is a common, recurrent and primary headache disorder. optimisation of novel cis- and trans-4-(substituted-anfido)benzopyran-3-ol derivatives has led to the identification of tonabersat (sb-220453) with potential antimigraine activity.
Biochem/physiol Actions
Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
in vitro
topiramate targets multiple cortical and subcortical loci, altering voltage-gated ion channels and chemical transmission to decrease abnormal brain excitability. preclinical studies have identified four properties that may account for the drug’s efficacy in epilepsy and migraine prophylaxis: (i) blockage of voltage-dependent sodium channels; (ii) augmentation of the activity of the neurotransmitter g-aminobutyric acid (gaba) at some subtypes of the gaba-a receptor; (iii) antagonism of the ampa/kainate subtype of the glutamate receptor; and (iv) inhibition of the carbonic anhydrase enzymes, particularly isozymes ii and iv [1].
in vivo
tonabersat binds selectively to a unique site in the brain. moreover, tonabersat could markedly reduce cortical spreading depression (csd) and csd-associated events and inhibite gap-junction communication between neurons and satellite glial cells in the trigeminal ganglion. together, these findings indicate that tonabersat should have clinical application in preventing migraine attacks [2].
References
[1] silberstein sd. tonabersat, a novel gap-junction modulator for the prevention of migraine. cephalalgia. 2009;29 suppl 2:28-35.
[2] durham pl, garrett fg. neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. cephalalgia. 2009;29 suppl 2:1-6.
[3] hauge aw, asghar ms, schytz hw, christensen k, olesen j. effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. lancet neurol. 2009;8(8):718-23.
TONABERSAT Preparation Products And Raw materials
Raw materials
Preparation Products
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