ChemicalBook > CAS DataBase List > 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

Product Name
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS No.
552-54-5
Chemical Name
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Synonyms
C.I.75700;RhaMnacine;NSC 678106;rhamnacene;RHAMNAZIN(SH);3,7-DIMETHYLQUERCETIN;7,3'-DiMethylquercetin;3',7-Di-O-Methylquercetin;7,3'-Di-O-methylquercetin;QUERCETIN-3,7-DIMETHYL ETHER
CBNumber
CB3409525
Molecular Formula
C17H14O7
Formula Weight
330.29
MOL File
552-54-5.mol
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3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Property

Melting point:
214-215 °C
Boiling point:
591.6±50.0 °C(Predicted)
Density 
1.507±0.06 g/cm3(Predicted)
pka
6.14±0.40(Predicted)
form 
powder
BRN 
338203
InChI
InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-10(18)12(5-8)23-2/h3-7,18-19,21H,1-2H3
InChIKey
MYMGKIQXYXSRIJ-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(OC)=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1O
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
93815
Product name
Rhamnazin
Purity
≥99% (HPLC)
Packaging
5mg
Price
$226
Updated
2025/07/31
TRC
Product number
D479175
Product name
3’,7-Di-O-methylQuercetin
Packaging
50mg
Price
$1540
Updated
2021/12/16
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3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties,Usage,Production

Uses

Di-O-methylated flavanol; a polyphenolic metabolite of Rhamnus disperma.

Definition

ChEBI: A dimethoxyflavone that is quercetin in which the hydroxy groups at the 3' and 7 positions have been replaced by methoxy groups.

in vivo

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2].

Animal Model:BALB/c nude mice, breast cancer xenograft model[1]
Dosage:200 mg/kg
Administration:Intragastric administration, daily for 25 days
Result:Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.

IC 50

VEGFR2: 4.68 μM (IC50)

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Suppliers

Canada 1 China 62 United Kingdom 2 United States 3 USA 1 Global 69
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
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United States
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ChromaDex
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sales@chromadex.com
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View Lastest Price from 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE manufacturers

Career Henan Chemical Co
Product
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE 552-54-5
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

552-54-5, 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONERelated Search:


  • rhamnacene
  • 7,3'-DiMethylquercetin
  • NSC 678106
  • Quercetin 7,3'-DiMethyl Ether
  • RhaMnacine
  • RHAMNAZIN(SH)
  • 3,7-DIMETHYLQUERCETIN
  • 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
  • QUERCETIN-3,7-DIMETHYL ETHER
  • 3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
  • 3',7-Di-O-Methylquercetin
  • 7,3'-Di-O-methylquercetin
  • C.I.75700
  • 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-
  • 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one
  • Quercetin 3’,7-Dimethyl ether
  • 3′,7-Di-O-methyl Quercetin, CAS 552-54-5
  • 552-54-5
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals