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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

Product Name
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
CAS No.
2232-08-8
Chemical Name
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
Synonyms
TosI;Tosylimidazole;1-TOSYLIMIDAZOLE;1-Tosyl-1H-imidazole;1-(p-Toluenesulfonyl;1-(4-Tolylsulfonyl)imidazole;1-(P-TOLUENESULFONYL)IMIDAZOLE;1-(p-toluenesulphonyl)imidazole;1-(TOLUENE-4-SULFONYL)IMIDAZOLE;1-(PARA-TOLUENESULPHONYL)IMIDAZOLE
CBNumber
CB3414604
Molecular Formula
C10H10N2O2S
Formula Weight
222.26
MOL File
2232-08-8.mol
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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Property

Melting point:
76-78 °C(lit.)
Boiling point:
409.1±38.0 °C(Predicted)
Density 
1.3038 (rough estimate)
refractive index 
1.5650 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
chloroform: soluble25mg/mL, clear, colorless to faintly yellow
form 
Crystals or Crystalline Powder
pka
1.22±0.10(Predicted)
color 
White to slightly yellow
Sensitive 
Moisture Sensitive
BRN 
612451
InChI
InChI=1S/C10H10N2O2S/c1-9-2-4-10(5-3-9)15(13,14)12-7-6-11-8-12/h2-8H,1H3
InChIKey
YJYMYJRAQYREBT-UHFFFAOYSA-N
SMILES
C1N(S(C2=CC=C(C)C=C2)(=O)=O)C=CN=1
CAS DataBase Reference
2232-08-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
F 
10-21
HS Code 
29332900
Storage Class
11 - Combustible Solids
Hazard Classifications
Aquatic Chronic 3
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
244244
Product name
1-(p-Toluenesulfonyl)imidazole
Purity
99%
Packaging
5G
Price
$21
Updated
2023/01/07
TCI Chemical
Product number
T1985
Product name
1-(p-Toluenesulfonyl)imidazole
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
T1985
Product name
1-(p-Toluenesulfonyl)imidazole
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$131
Updated
2025/07/31
TRC
Product number
T733858
Product name
1-(p-Toluenesulfonyl)imidazole
Packaging
50mg
Price
$45
Updated
2021/12/16
Ark Pharm
Product number
P000577170
Product name
1-(P-Toluenesulfonyl)imidazole
Purity
98%
Packaging
5g
Price
$6
Updated
2021/12/16
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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystals

Uses

Alcohols to azides in one step.1

Uses

1-(p-Toluenesulfonyl)imidazole was used in the synthesis of cationic water soluble cyclodextrin, mono-6A-(1-butyl-3-imidazolium)-6A-deoxy-β-cyclodextrin chloride (BIMCD), useful in chiral separation of amino acids and anionic pharmaceuticals by capillary electrophoresis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 547, 1980 DOI: 10.1021/jo01291a044

General Description

1-(p-Toluenesulfonyl)imidazole converts alcohols to azides in one step.

Synthesis

288-32-4

98-59-9

2232-08-8

(a) In a three-necked round-bottomed flask equipped with a charging funnel, oil collector, magnetic stirring bar and protected by argon, imidazole (5.502 g, 0.081 mol) was dissolved in 25 mL of anhydrous dichloromethane. After cooling the solution to 0°C, p-toluenesulfonyl chloride (6.78 g, 0.036 mol) dissolved in 25 mL of anhydrous dichloromethane was added slowly and dropwise. The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was subsequently filtered through silica gel and the residual solid was washed with 50 mL hexane/ethyl acetate (1:1, v/v). The filtrate was concentrated in a rotary evaporator, redissolved in 6 mL of ethyl acetate and precipitation was induced by the addition of 60 mL of hexane. The resulting white solid was filtered and dried to give 7.12 g of 1-tosylimidazole (0.032 mol, 89% yield).

References

[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 7, p. 2209 - 2218
[2] Organic Syntheses, 2000, vol. 77, p. 225 - 225
[3] Tetrahedron, 2016, vol. 72, # 3, p. 379 - 391
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 1855 - 1858
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 9, p. 1867 - 1875

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Preparation Products And Raw materials

Raw materials

Chloroform Tosyl chloride Imidazole

Preparation Products

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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Suppliers

Belgium 2 Canada 1 China 211 Europe 1 France 1 Germany 4 India 4 Japan 2 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 19 Global 257
Suzhou Highfine Biotech Co., Ltd
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0512-68417696 13962195629
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Heze Bona Medical Technology Co., LTD
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614989876@qq.com
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J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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TCI (Shanghai) Development Co., Ltd.
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Sales-CN@TCIchemicals.com
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ShangHai DEMO Chemical Co.,Ltd
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400-021-7337 2355568890
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0086-21-50182339
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sales@demochem.com
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Energy Chemical
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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+86-10-82967029
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2355560935@qq.com
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JinYan Chemicals(ShangHai) Co.,Ltd.
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13817811078
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86-021-50426522,50426273
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sales@jingyan-chemical.com
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View Lastest Price from 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

2232-08-8, 1-[(4-Methylphenyl)sulfonyl]-1H-imidazoleRelated Search:

Xylene Levamisole Imidazole Sulfuryl chloride p-Toluenesulfonic acid Dimethyl sulfone 4-(Trifluoromethyl)benzene-1-sulfonyl chloride Mebendazole 4-Methylbenzenesulfonhydrazide Boc-L-Histidine(Tosyl) BOC-HIS(TOS)-MERRIFIELD RESIN 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole N-MESITYLENESULFONYLIMIDAZOLE N-Boc-N'-tosyl-D-histidine FMOC-HIS(TOS)-OH N-ALPHA-(3-NITRO-2-PYRIDINESULFENYL)-N-IM-TOSYL-L-HISTIDINE BOC-HIS(TOS)-OH DCHA BOC-D-HIS(TOS)-OH DCHA

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  • 1-(p-Toluenesulfonyl)imidazole, 98+% white solid
  • 4-Methylphenyl(1H-imidazole-1-yl) sulfone
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  • 1-(Toluene-4-sulphonyl)-1H-imidazole
  • 1-Tosyl-1H-imidazole, 1-[(4-Methylphenyl)sulphonyl]-1H-imidazole
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  • 2232-08-8
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  • 2322-08-8
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