ChemicalBook > CAS DataBase List > N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
- Product Name
- N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
- CAS No.
- 498577-46-1
- Chemical Name
- N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide
- Synonyms
- A 1899;S20951;S 20951;S-20951;N-(2,4-Difluorobenzyl)-2'-((2-(4-methoxyphenyl)acetamido)methyl)-[1,1'-biphenyl]-2-carboxamide;N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide;[1,1'-Biphenyl]-2-carboxamide, N-[(2,4-difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-
- CBNumber
- CB34200564
- Molecular Formula
- C30H26F2N2O3
- Formula Weight
- 500.54
- MOL File
- 498577-46-1.mol
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N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Property
- Boiling point:
- 756.5±60.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 13.51±0.46(Predicted)
- color
- white to beige
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N-Bromosuccinimide Price
Tocris
- Product number
- 6972
- Product name
- A1899
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $89
- Updated
- 2021/12/16
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N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Chemical Properties,Usage,Production
Biological Activity
Potent and selective TASK-1 potassium channel blocker th at induces lasting respiratory alkalosis and stimulates breathing in anesthetized rats.
A1899 is a highly potent and selective non-voltage-dependent two-pore domain potassium channel K 2P 3.1 blocker (TASK-1, KCNK3, IC50 = 7 nM in CHO cells) with 10-fold selectivity over TASK-3 and much reduced or little potency towards TASK-2/4 (>8 μM in Xenopus oocytes) and other potassium channels. A1899 specifically blocks TASK-1 currents by 74% in Xenopus oocytes at 100 nM via an open-channel block mechanism. A1899 induces lasting respiratory alkalosis and stimulates breathing in anesthetized rats in vivo (5-25 mg/kg, i.v.). Also mitigates the endothelin-1 induced prolonged action potential duration in cardiomyocytes ( at 200 nM).
storage
Store at -20°C
N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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N-[(2,4-difluorophenyl)methyl]-2'-{[2-(4-methoxyphenyl)acetamido]methyl}-[1,1'-biphenyl]-2-carboxamide Suppliers
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