3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID
- Product Name
- 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID
- CAS No.
- 832695-88-2
- Chemical Name
- 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID
- Synonyms
- 3-(N-MethyL;aminocarbonyL;3-Borono-N-methylbenzamide;3-(Methylcarbamoyl)benzeneboronic acid;[3-(MethylcarbaMoyl)phenyl]boronic acid;3-(N-Methylcarbamoyl)benzeneboronic acid;3-(N-methylformionine)phenylboronic acid;3-(MethylaMinocarbonyl)benzeneboronic Acid;[3-(MethylaMinocarbonyl)phenyl]boronic Acid;3-(N-methylaminocarbonyl)phemylboronic acid
- CBNumber
- CB3430637
- Molecular Formula
- C8H10BNO3
- Formula Weight
- 178.98
- MOL File
- 832695-88-2.mol
3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID Property
- Melting point:
- 114-124°C
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.70±0.10(Predicted)
- form
- solid
- color
- white
- CAS DataBase Reference
- 832695-88-2
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-43-41-37/38-22
- Safety Statements
- 26-36/37/39-39-36/37
- Hazard Note
- Irritant
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M285775
- Product name
- 3-(Methylaminocarbonyl)benzeneboronicAcid
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- OR10554
- Product name
- 3-(Methylcarbamoyl)benzeneboronicacid
- Packaging
- 250mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 8660-1-V5
- Product name
- 3-(Methylcarbamoyl)benzeneboronic acid
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- OR10554
- Product name
- 3-(Methylcarbamoyl)benzeneboronicacid
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 8660-1-V5
- Product name
- 3-(Methylcarbamoyl)benzeneboronic acid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID Chemical Properties,Usage,Production
Uses
3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID is used in the preparation of thiazolopyridinylacetamide derivatives and analogs for use as PI3K and mTOR kinase inhibitors.
Synthesis
3.0 g (8.85 mmol) of potassium phosphate heptahydrate, 1.50 g (5.90 mmol) of bis(boronic acid) pinacol ester B2(pin)2, 12 mg (0.015 mmol) of Xphos-Pd-G2, and 4 mg (0.008 mmol) of Xphos were added sequentially to a reaction vial with 6 mL of ethanol stirred to mix well, and then 0.36 mL (2.95 mmol) 3-(N-methylformylamino)chlorobenzene was added and the reaction was carried out at room temperature for 1 hour. The reaction solution was diluted by adding 5 mL of ethyl acetate, filtered through diatomaceous earth, washed with ethyl acetate, the filtrates were combined and concentrated under reduced pressure to obtain the crude product, which was separated by silica gel column chromatography, eluted with petroleum ether-ethyl acetate, to obtain 3-(N-methylformylammonio)phenylboronic acid pinacol ester. 3-(N-Methylformylammonio)phenylboronic acid pinacol ester was added to a reaction vial and hydrolyzed dropwise with dilute HCl. The solution first produced a precipitate, and as the precipitate gradually disappeared, the pH of the system was adjusted to 1. NaOH solution with a mass fraction of 25% was added dropwise to the solution to pH 13, and stirred for 1 h. The solution was partitioned, and the organic phase was extracted with 15 mL of NaOH with a mass fraction of 10%, and the aqueous phases were combined, and the bases were extracted with 15 mL of THF for 2 times, respectively. The pH of the obtained base solution was adjusted with dilute HCl, turbidity was produced at the beginning, flocculent appeared slowly, and the pH was adjusted to 5.0. The aqueous phase was extracted with 70 mL of THF, and the organic phase was spin-dried and purified to obtain 3-(N-methylformylamino)phenylboronic acid.
3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11777
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9892
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
View Lastest Price from 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID manufacturers
- Product
- 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID 832695-88-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID 832695-88-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 3-(N-METHYLAMINOCARBONYL)PHENYLBORONIC ACID 832695-88-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04