7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL

Product Name: 7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL
CAS No.: 6632-09-3
Chemical Name: 7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL
Synonyms: AURORA 23227;AKOS BBS-00001111;OTAVA-BB BB7010150234;NSC57969 >=98% (HPLC);7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL;8-Quinolinol, 7-(1-piperidinylmethyl)-;7-(1-piperidinylmethyl)-8-hydroxyquinoline
CBNumber: CB3434857
Molecular Formula: C15H18N2O
Formula Weight: 242.32
MOL File: Mol file

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7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Property

Melting point:: 194 °C
Boiling point:: 402.4±30.0 °C(Predicted)
Density: 1.202±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 5mg/mL, clear (warmed)
pka: 3.81±0.50(Predicted)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1863
Product name: NSC57969
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $69.54
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1863
Product name: NSC57969
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $376
Updated: 2022/05/15

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7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Chemical Properties,Usage,Production

Uses

NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines[1].

Biological Activity

NSC57969 is a MDR-selective compound th at exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

References

[1] András Füredi, et al. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity. Mol Cancer Ther. 2017 Jan;16(1):45-56. DOI:10.1158/1535-7163.MCT-16-0333-T

7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL Suppliers

Austria 1 China 4 Germany 1 Ukraine 1 United States 3 Global 10

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
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Energy Chemical

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Email: marketing@energy-chemical.com
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Merck KGaA

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Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
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Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
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6632-09-3, 7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OLRelated Search:

5-Quinolinesulfonic acid, 7-bromo-8-hydroxy- 8-Quinolinol,5-bromo-7-nitro-

OTAVA-BB BB7010150234

7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL

AKOS BBS-00001111

AURORA 23227

7-(1-piperidinylmethyl)-8-hydroxyquinoline

8-Quinolinol, 7-(1-piperidinylmethyl)-

NSC57969 >=98% (HPLC)

6632-09-3