6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE
- Product Name
- 6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE
- CAS No.
- 50501-38-7
- Chemical Name
- 6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE
- Synonyms
- 6-(HydroxyMethyl)picolinonitrile;6-HYDROXYMETHYL-2-CYANO-PYRIDINE;6-Hydroxymethyl-pyridine-2-carbonitrile;6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE;2-Pyridinecarbonitrile, 6-(hydroxymethyl)-
- CBNumber
- CB3436639
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 50501-38-7.mol
6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE Property
- Boiling point:
- 310.5±27.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 12.89±0.10(Predicted)
- form
- solid
- color
- Beige
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A415850
- Product name
- 6-(Hydroxymethyl)picolinonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 5066CV
- Product name
- 6-(Hydroxymethyl)picolinonitrile
- Packaging
- 250mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- OR346651
- Product name
- 6-Hydroxymethylpyridine-2-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $379
- Updated
- 2021/12/16
- Product number
- 5066CV
- Product name
- 6-(Hydroxymethyl)picolinonitrile
- Packaging
- 1g
- Price
- $439
- Updated
- 2021/12/16
- Product number
- CHM0012926
- Product name
- 6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1431.05
- Updated
- 2021/12/16
6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE Chemical Properties,Usage,Production
Synthesis
39621-11-9
50501-38-7
The general procedure for the synthesis of 6-(hydroxymethyl)pyridine carboxaldehyde from 6-(hydroxymethyl)pyridine is as follows:P3: The alternative synthetic method is detailed in references [35-37]. The reaction was carried out under nitrogen protection. Hydroxylamine hydrochloride (600 mg, 8.63 mmol; excess) and 6-(hydroxymethyl)pyridine carboxaldehyde (750 mg, 5.47 mmol) were dissolved in DMSO (3 mL; 99.7% purity, degassed, additional drying treatment, sieved, moisture content <50 ppm, purchased from Acros), and reacted with stirring for 2 h at 100 °C (oil-bath temperature), the reaction solution was The reaction solution was dark red in color. After completion of the reaction, extraction was carried out with dichloromethane and saturated sodium bicarbonate solution. The aqueous phase was washed with saturated sodium chloride solution. The organic phase is re-extracted with saturated sodium bicarbonate solution to remove residual DMSO. the aqueous phase is back-extracted with dichloromethane in order to completely remove DMSO (due to its solubility in water) without loss of product. The organic phases were combined, concentrated by evaporation and purified by silica gel column chromatography (20 g), eluting first with dichloromethane to remove impurities and then with dichloromethane solution containing 0.5% methanol to give the target product. The product was a pale yellow solid with a yield of 446 mg (3.32 mmol; 61% yield; molecular formula C7H6N2O; molecular weight 134.14.
References
[1] Inorganica Chimica Acta, 2015, vol. 427, p. 81 - 86
6-(HYDROXYMETHYL)-2-PYRIDINECARBONITRILE Preparation Products And Raw materials
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