METHYL (4-CYANOPHENYL)ACETATE

Product Name: METHYL (4-CYANOPHENYL)ACETATE
CAS No.: 52798-01-3
Chemical Name: METHYL (4-CYANOPHENYL)ACETATE
Synonyms: METHYL 2-(4-CYANOPHENYL)ACETATE;METHYL (4-CYANOPHENYL)ACETATE;4-Cyanophenylacetic acid methyl ester;4-Cyanobenzeneacetic acid methyl ester;p-Cyanophenyl acetic acid methyl ester;Benzeneacetic acid, 4-cyano-, Methyl ester
CBNumber: CB3442290
Molecular Formula: C10H9NO2
Formula Weight: 175.18
MOL File: 52798-01-3.mol

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METHYL (4-CYANOPHENYL)ACETATE Property

Melting point:: 221 °C
Boiling point:: 289.9±23.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
color: Off-white
InChI: InChI=1S/C10H9NO2/c1-13-10(12)6-8-2-4-9(7-11)5-3-8/h2-5H,6H2,1H3
InChIKey: OHTZXQYRHDVXLJ-UHFFFAOYSA-N
SMILES: C1(CC(OC)=O)=CC=C(C#N)C=C1

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3276
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: M338108
Product name: Methyl(4-cyanophenyl)acetate
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M338108
Product name: Methyl(4-cyanophenyl)acetate
Packaging: 10g
Price: $360
Updated: 2021/12/16

Matrix Scientific

Product number: 076527
Product name: Methyl (4-cyanophenyl)acetate
Purity: 95+%
Packaging: 1g
Price: $416
Updated: 2021/12/16

Apolloscientific

Product number: OR912751
Product name: Methyl(4-cyanophenyl)acetate
Purity: 98%
Packaging: 10g
Price: $435
Updated: 2021/12/16

AK Scientific

Product number: J50943
Product name: Methyl(4-cyanophenyl)acetate
Packaging: 25g
Price: $475
Updated: 2021/12/16

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METHYL (4-CYANOPHENYL)ACETATE Chemical Properties,Usage,Production

Uses

Methyl (4-cyanophenyl)acetate was a useful reagent in studying pyrazolopyridinones as functionally selective GABAA ligands.

Synthesis

67-56-1

5462-71-5

52798-01-3

The general procedure for the synthesis of methyl 2-(4-cyanophenyl)acetate from methanol and 4-cyanophenylacetic acid was as follows: concentrated sulfuric acid (98%, 4.5 g, 54.8 mmol) was added slowly and dropwise to 40 ml of methanol solution of 4-cyanophenylacetic acid (3 g, 18.0 mmol), and the reaction mixture was stirred for 4 h at room temperature. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate solution to 8. Subsequently, the reaction mixture was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 2-(4-cyanophenyl)acetate 3.2 g in 98% yield.

References

[1] Journal of Organic Chemistry, 2009, vol. 74, # 6, p. 2598 - 2600
[2] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0602; 0603; 0604
[3] Patent: WO2013/8162, 2013, A1. Location in patent: Page/Page column 58; 59
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 2, p. 131 - 134

METHYL (4-CYANOPHENYL)ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL (4-CYANOPHENYL)ACETATE Suppliers

Canada 1 China 101 France 1 Germany 1 India 2 United Kingdom 3 United States 9 Global 118

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Shanghai Topbiochem Technology Co., Ltd

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View Lastest Price from METHYL (4-CYANOPHENYL)ACETATE manufacturers

Career Henan Chemical Co

Product: METHYL (4-CYANOPHENYL)ACETATE 52798-01-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

52798-01-3, METHYL (4-CYANOPHENYL)ACETATERelated Search:

METHYL (3-CYANOPHENYL)ACETATE METHYL (2-CYANOPHENYL)ACETATE ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE DIETHYL 2-(4-CYANOPHENYL)MALONATE ETHYL 4-CYANOBENZOYLFORMATE METHYL (4-CYANOPHENYL)ACETATE METHYL 2-BROMO-2-(4'-CYANOPHENYL)ACETATE 6,8-DICHLORO-3-CYANO-4-(4'-HYDROXYPHENYL)COUMARIN ethyl 2-(4-cyanophenyl)acetate (2,3,5,6-TETRAFLUORO-4-CYANOPHENYL)MALONIC ACID DIMETHYL ESTER 4-CYANOMANDELIC ACID ETHYL ESTER (3-CHLORO-4-CYANO-PHENYL)-ACETIC ACID METHYL ESTER

Benzeneacetic acid, 4-cyano-, Methyl ester

METHYL (4-CYANOPHENYL)ACETATE

METHYL 2-(4-CYANOPHENYL)ACETATE

p-Cyanophenyl acetic acid methyl ester

4-Cyanophenylacetic acid methyl ester

4-Cyanobenzeneacetic acid methyl ester

52798-01-3

Aromatic Esters

pharmacetical