R-(-)-Apomorphine
- Product Name
- R-(-)-Apomorphine
- CAS No.
- 41372-20-7
- Chemical Name
- R-(-)-Apomorphine
- Synonyms
- Apokyn;R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE;r-(-)-apomorphine;Apokyn HeMihydrate;Ixense HeMihydrate;ApoMorphin HeMihydrate;ApoMorphine HeMihydrate;Apomorphine HCl hydrate;APOMORPHINEHCLHEMIHYDRATE;Apomophine hydrochloride
- CBNumber
- CB3447114
- Molecular Formula
- C17H20ClNO3
- Formula Weight
- 321.8
- MOL File
- 41372-20-7.mol
R-(-)-Apomorphine Property
- Melting point:
- 285-287 °C(lit.)
- alpha
- -48 º (c=1, H2O)
- storage temp.
- Refrigerator
- solubility
- H2O: ~10 mg/mL, clear, yellow-green
- form
- Solid
- color
- white to gray
- PH
- pH(10g/l, 25℃) : 4.0～5.0
- Water Solubility
- H2O: ~10mg/mL, clear, yellow-green
- Merck
- 13,751
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
- CAS DataBase Reference
- 41372-20-7(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- Y0001465
- Product name
- Apomorphine hydrochloride hemihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 15 mg
- Price
- $225
- Updated
- 2025/07/31
- Product number
- PHR2621
- Product name
- Apomorphine hydrochloride
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
- Packaging
- 500MG
- Price
- $243
- Updated
- 2025/07/31
- Product number
- A4393
- Product name
- R-(?)-Apomorphine hydrochloride hemihydrate
- Purity
- calcined, ≥98.5%
- Packaging
- 1g
- Price
- $298
- Updated
- 2025/07/31
- Product number
- 1041008
- Product name
- Apomorphine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 250mg
- Price
- $489
- Updated
- 2025/07/31
- Product number
- A4393
- Product name
- R-(?)-Apomorphine hydrochloride hemihydrate
- Purity
- calcined, ≥98.5%
- Packaging
- 100mg
- Price
- $56.33
- Updated
- 2025/07/31
R-(-)-Apomorphine Chemical Properties,Usage,Production
Description
Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5
Chemical Properties
Off-White Solid
Uses
emetic, antiparkinsonian, erextile dysfunction therapy
Uses
R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.
Uses
Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
brand name
Apokyn (Vernalis).
Purification Methods
Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.
References
[1] Merck’s Index, Nachtrag 1930. Verlag von E. Merck, Darmstadt. 14 Seiten[J]. Archiv der Pharmazie, 1930, 268 6: 444-445. DOI:10.1002/ardp.19302680608
[2] MARK J MILLAN. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.[J]. Journal of Pharmacology and Experimental Therapeutics, 2002, 303 2: 791-804. DOI:10.1124/jpet.102.039867
[3] EDNA GRÜNBLATT DSC (STUDENT). Apomorphine protects against MPTP-induced neurotoxicity in mice[J]. Movement Disorders, 2001, 14 4: 612-618. DOI:10.1002/1531-8257(199907)14:4<612::aid-mds1010>3.0.co;2-6
[4] MANON AUFFRET . Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations[J]. Journal of the Neurological Sciences, 2017, 372: Pages 279-287. DOI:10.1016/j.jns.2016.11.080
[5] PETER JENNER Regina K. Apomorphine - pharmacological properties and clinical trials in Parkinson’s disease[J]. Parkinsonism & related disorders, 2016, 33: Pages S13-S21. DOI:10.1016/j.parkreldis.2016.12.003
R-(-)-Apomorphine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from R-(-)-Apomorphine manufacturers
- Product
- R-(-)-Apomorphine 41372-20-7
- Price
- US $11500.00-11460.00/kilograms
- Min. Order
- 10kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-17
- Product
- R-(-)-Apomorphine 41372-20-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-06-29