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R-(-)-Apomorphine

Product Name
R-(-)-Apomorphine
CAS No.
41372-20-7
Chemical Name
R-(-)-Apomorphine
Synonyms
Apokyn;R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE;r-(-)-apomorphine;Apokyn HeMihydrate;Ixense HeMihydrate;ApoMorphin HeMihydrate;ApoMorphine HeMihydrate;Apomorphine HCl hydrate;APOMORPHINEHCLHEMIHYDRATE;Apomophine hydrochloride
CBNumber
CB3447114
Molecular Formula
C17H20ClNO3
Formula Weight
321.8
MOL File
41372-20-7.mol
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R-(-)-Apomorphine Property

Melting point:
285-287 °C(lit.)
alpha 
-48 º (c=1, H2O)
storage temp. 
Refrigerator
solubility 
H2O: ~10 mg/mL, clear, yellow-green
form 
Solid
color 
white to gray
PH
pH(10g/l, 25℃) : 4.0～5.0
Merck 
13,751
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
CAS DataBase Reference
41372-20-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HS Code 
2933997000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2621
Product name
Apomorphine hydrochloride
Purity
PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging
500MG
Price
$226
Updated
2024/03/01
Sigma-Aldrich
Product number
A4393
Product name
R-(?)-Apomorphine hydrochloride hemihydrate
Purity
calcined, ≥98.5%
Packaging
1g
Price
$290
Updated
2024/03/01
Sigma-Aldrich
Product number
1041008
Product name
Apomorphine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$457
Updated
2024/03/01
Sigma-Aldrich
Product number
A4393
Product name
R-(?)-Apomorphine hydrochloride hemihydrate
Purity
calcined, ≥98.5%
Packaging
100mg
Price
$57.7
Updated
2024/03/01
Sigma-Aldrich
Product number
A4393
Product name
R-(?)-Apomorphine hydrochloride hemihydrate
Purity
calcined, ≥98.5%
Packaging
250mg
Price
$95.3
Updated
2024/03/01
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R-(-)-Apomorphine Chemical Properties,Usage,Production

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical Properties

Off-White Solid

Uses

emetic, antiparkinsonian, erextile dysfunction therapy

Uses

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

Uses

Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.

brand name

Apokyn (Vernalis).

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

R-(-)-Apomorphine Preparation Products And Raw materials

Raw materials

MORPHINE Sodium sulfite CHLOROETHANE Activated carbon,decolor

Preparation Products

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R-(-)-Apomorphine Suppliers

Canada 1 China 45 France 1 Germany 1 India 8 Japan 1 South Korea 1 Switzerland 1 United Kingdom 8 United States 22 Global 89
Carbosynth
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sales@carbosynth.com
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United Kingdom
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MACFARLAN SMITH LIMITED
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enquiry@macsmith.com
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Whyte Chemicals
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United Kingdom
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Leancare Ltd.
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enquiry@leancare.co.uk
Country
United Kingdom
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MOLEKULA Ltd.
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kevinbanks@molekula.com
Country
United Kingdom
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CARBONE SCIENTIFIC CO.,LTD
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ETA SCIENTIFIC Co.,Ltd
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sales@etascientific.com
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UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
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View Lastest Price from R-(-)-Apomorphine manufacturers

Hebei Dangtong Import and export Co LTD
Product
R-(-)-Apomorphine 41372-20-7
Price
US $11500.00-11460.00/kilograms
Min. Order
10kilograms
Purity
99%
Supply Ability
100tons
Release date
2023-02-17
Henan Bao Enluo International TradeCo.，LTD
Product
R-(-)-Apomorphine 41372-20-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
50000tons
Release date
2023-06-29

41372-20-7, R-(-)-ApomorphineRelated Search:

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  • a . N-(2-a mi noe th yl)-2-(b e nzylph e nyla mi no)a c e ta mi d e .
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  • 41372-20-7
  • C17H18ClNO212H2O
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  • C17H17NO222HClH2O
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  • 31279
  • Nonselective dopamine agonist; causes nausea and emesis.
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Others
  • Heterocyclic Building Blocks
  • Inhibitors
  • APOKYN
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Agonists
  • Dopaminergics
  • Neurotransmitters
  • Erectile Dysfunction
  • Dopamine receptor