R-(-)-Apomorphine

Product Name: R-(-)-Apomorphine
CAS No.: 41372-20-7
Chemical Name: R-(-)-Apomorphine
Synonyms: Apokyn;R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE;r-(-)-apomorphine;Apokyn HeMihydrate;Ixense HeMihydrate;ApoMorphin HeMihydrate;ApoMorphine HeMihydrate;Apomorphine HCl hydrate;APOMORPHINEHCLHEMIHYDRATE;Apomophine hydrochloride
CBNumber: CB3447114
Molecular Formula: C17H20ClNO3
Formula Weight: 321.8
MOL File: 41372-20-7.mol

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R-(-)-Apomorphine Property

Melting point:: 285-287 °C(lit.)
alpha: -48 º (c=1, H2O)
storage temp.: Refrigerator
solubility: H₂O: ~10 mg/mL, clear, yellow-green
form: Solid
color: white to gray
PH: pH(10g/l, 25℃) : 4.0～5.0
Merck: 13,751
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
CAS DataBase Reference: 41372-20-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HS Code: 2933997000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2621
Product name: Apomorphine hydrochloride
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 500MG
Price: $226
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4393
Product name: R-(?)-Apomorphine hydrochloride hemihydrate
Purity: calcined, ≥98.5%
Packaging: 1g
Price: $290
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1041008
Product name: Apomorphine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $457
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4393
Product name: R-(?)-Apomorphine hydrochloride hemihydrate
Purity: calcined, ≥98.5%
Packaging: 100mg
Price: $57.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4393
Product name: R-(?)-Apomorphine hydrochloride hemihydrate
Purity: calcined, ≥98.5%
Packaging: 250mg
Price: $95.3
Updated: 2024/03/01

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R-(-)-Apomorphine Chemical Properties,Usage,Production

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical Properties

Off-White Solid

Uses

emetic, antiparkinsonian, erextile dysfunction therapy

Uses

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

Uses

Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.

brand name

Apokyn (Vernalis).

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

R-(-)-Apomorphine Preparation Products And Raw materials

Raw materials

MORPHINE Sodium sulfite CHLOROETHANE Activated carbon,decolor

Preparation Products

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R-(-)-Apomorphine Suppliers

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View Lastest Price from R-(-)-Apomorphine manufacturers

Hebei Dangtong Import and export Co LTD

Product: R-(-)-Apomorphine 41372-20-7
Price: US $11500.00-11460.00/kilograms
Min. Order: 10kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-02-17

Henan Bao Enluo International TradeCo.，LTD

Product: R-(-)-Apomorphine 41372-20-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-06-29

41372-20-7, R-(-)-ApomorphineRelated Search:

Quinhydrone Ethoxyquin Methyl acetate 8-Hydroxyquinoline Kresoxim-methyl Thiophanate-methyl Methyl acrylate Bensulfuron methyl Quinoline Yellow 2-METHYL-1,3-PROPANEDIOL Isoquinoline Poly(tetrahydrofuran) Methylparaben Quinclorac Methyl Parathion-methyl MORPHINE apomorphine

(r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol

Apomorphine hydrochloride R-(-)-

(6Ar)-5,6,6A,7-tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid

6a-beta-aporphine-10,11-diol

APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE

4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)-

APOMORPHINEHCLHEMIHYDRATE

APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP

Apomophine hydrochloride

R-(-)-Apomorphine hemihydrate hydrochloride

4H-Dibenzo(de,G)quinoline-10,11-diol, 5,6,6A,7-tetrahydro-6-methyl-, hydrochloride, hemihydrate, (R)-

Apokyn

Apomorphin hydrochlorid wasser (2/1)

Apomorphine Hydrochloride (250 mg)

(-)-10,11-Dihydroxy-aporphine Hydrochloride HeMihydrate

(6aR)-5,6,6a,7-Tetrahydro-6-Methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride HeMihydrate

6aβ-Aporphine-10,11-diol Hydrochloride HeMihydrate

Apokyn HeMihydrate

ApoMorphin HeMihydrate

ApoMorphine HeMihydrate

Ixense HeMihydrate

l-ApoMorphine HeMihydrate

r-(-)-apomorphine:6a-beta-aporphine-10,11-diol: (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)QUINOLINE-10,11-diol

R-(-)-Apomorphine HCl Hemihydrate

R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE

r-(-)-apomorphine

Apomorphine hydrochloride hemihydrate CRS

Apomorphine HCl hydrate

R-(-)-Apomorphine USP/EP/BP

Apomorphine Hydrochloride (1041008)

a . N-(2-a mi noe th yl)-2-(b e nzylph e nyla mi no)a c e ta mi d e .

Apomorphine HCl Reference Standard

Apomorphine hydrochloride hemihydrate in methanol

41372-20-7

C17H18ClNO212H2O

C17H17NO2HCl12H2O

C17H17NO222HClH2O

C17H20ClNO3

C17H18ClNO2H2O

31279

Nonselective dopamine agonist; causes nausea and emesis.

Chiral Building Blocks

Asymmetric Synthesis

Others

Heterocyclic Building Blocks

Inhibitors

APOKYN

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Agonists

Dopaminergics

Neurotransmitters

Erectile Dysfunction

Dopamine receptor