ChemicalBook > CAS DataBase List > 4-(METHANESULFONYLAMINO)PHENYLACETIC ACID

4-(METHANESULFONYLAMINO)PHENYLACETIC ACID

Product Name
4-(METHANESULFONYLAMINO)PHENYLACETIC ACID
CAS No.
56205-88-0
Chemical Name
4-(METHANESULFONYLAMINO)PHENYLACETIC ACID
Synonyms
Dofetilide Impurity 13;Dofetilide Impurity 19;2-(4-(Methylsulfonamido);4-(Methanesulfonylamino)phenylacetic;2,2'-Biquinoline-4,4'-diyl bis(arsine);P-(METHANESULFONAMIDO)PHENYLACETIC ACID;4-(Methylsulphonylamino)phenylaceticAci;p-(Methanesulfonamide)phenylacetic Acid;2-(4-Methanesulfonamidophenyl)acetic acid;4-(METHANESULFONYLAMINO)PHENYLACETIC ACID
CBNumber
CB3450178
Molecular Formula
C9H11NO4S
Formula Weight
229.25
MOL File
56205-88-0.mol
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4-(METHANESULFONYLAMINO)PHENYLACETIC ACID Property

Melting point:
146-149°C
Boiling point:
422.7±47.0 °C(Predicted)
Density 
1.456±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.28±0.10(Predicted)
form 
Solid
color 
Off-White to Pale Beige
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Safety

Hazard Codes 
C,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
Hazard Note 
Corrosive
HazardClass 
IRRITANT
HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M332220
Product name
2-(4-(Methylsulfonamido)phenyl)aceticAcid
Packaging
1g
Price
$180
Updated
2021/12/16
Matrix Scientific
Product number
056413
Product name
2-(4-Methanesulfonamidophenyl)acetic acid
Purity
>95%
Packaging
1g
Price
$142
Updated
2021/12/16
Apolloscientific
Product number
OR10894
Product name
4-[(Methylsulphonyl)amino]phenylaceticacid,
Purity
97+%
Packaging
1g
Price
$244
Updated
2021/12/16
SynQuest Laboratories
Product number
8769-1-Y3
Product name
4-[(Methylsulfonyl)amino]phenylacetic acid
Packaging
1g
Price
$269
Updated
2021/12/16
Matrix Scientific
Product number
056413
Product name
2-(4-Methanesulfonamidophenyl)acetic acid
Purity
>95%
Packaging
5g
Price
$450
Updated
2021/12/16
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4-(METHANESULFONYLAMINO)PHENYLACETIC ACID Chemical Properties,Usage,Production

Uses

2-(4-(Methylsulfonamido)phenyl)acetic Acid acts as a reagent for resiniferatoxin analogs preparation as metabolically stable TRPV1 agonists and potential analgesics. Preparation and structure-activity relationships of 2,6-diaryl-4-(phenacylamino)pyrimidines as selective adenosine A2A antagonists.

Synthesis

1197-55-3

124-63-0

56205-88-0

The general procedure for the synthesis of 4-methylsulfonylaminophenylacetic acid from 4-aminophenylacetic acid (1 g, 6.66 mmol) and methanesulfonyl chloride (0.77 g, 9.99 mmol) was as follows: first, 4-aminophenylacetic acid was dissolved in THF (10 mL), and pH was adjusted with a 1N sodium hydroxide solution to 9. Subsequently, a THF of methanesulfonyl chloride was added slowly and dropwise under stirring solution (10 mL), and the reaction mixture continued to stir the reaction. After completion of the reaction, the pH was adjusted to 3 with 1N hydrochloric acid, the reaction mixture was diluted with distilled water and extracted several times with ethyl acetate. The organic layers were combined, washed with water, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography using EtOAc/hexane (2:3) as eluent to give 0.855 g of yellow solid 4-(methylsulfonylamino)benzeneacetic acid in 56% yield. The product was characterized by 1H-NMR (DMSO-d6): δ 9.67 (s, 1H, COOH), 7.20 (d, 2H, J = 8.5 Hz, Ar-H), 7.13 (d, 2H, J = 8.5 Hz, Ar-H), 3.50 (s, 2H, CH2), 3.95 (s, 3H, SO2CH3).

References

[1] Patent: WO2004/35533, 2004, A1. Location in patent: Page 33
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2291 - 2297
[3] Patent: US6265445, 2001, B1

4-(METHANESULFONYLAMINO)PHENYLACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(METHANESULFONYLAMINO)PHENYLACETIC ACID Suppliers

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56205-88-0, 4-(METHANESULFONYLAMINO)PHENYLACETIC ACIDRelated Search:

3-(METHANESULFONYLAMINO)PHENYLACETIC ACID,3-(Methanesulfonylamino)phenylacetic acid, min. 95 %

  • P-(METHANESULFONAMIDO)PHENYLACETIC ACID
  • 4-(Methylsulphonylamino)phenylacetic acid
  • 4-(Methanesulfonylamino)phenylacetic
  • 4-(Methanesulfonylamino)phenylacetic acid, min. 95 %
  • p-(Methanesulfonamide)phenylacetic Acid
  • 2-(4-(MethylsulfonaMido)phenyl)acetic acid
  • 4-[(Methylsulfonyl)amino]benzeneacetic acid
  • 2-(4-(Methylsulfonamido)
  • 2-(4-Methanesulfonamidophenyl)acetic acid
  • N-[4-(Carboxymethyl)phenyl]methanesulphonamide, 4-(Methylsulphonamido)phenylacetic acid
  • 4-(METHANESULFONYLAMINO)PHENYLACETIC ACID
  • Dofetilide Impurity 13
  • 4-[(Methylsulphonyl)amino]phenylacetic acid, 97+%
  • Benzeneacetic acid, 4-[(methylsulfonyl)amino]-
  • 4-(Methylsulphonylamino)phenylaceticAci
  • Dofetilide Impurity 19
  • 2,2'-Biquinoline-4,4'-diyl bis(arsine)
  • 56205-88-0
  • Acids and Derivatives
  • Boron, Nitrile, Thio,& TM-Cpds