ChemicalBook > CAS DataBase List > N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE

N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE

Product Name
N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
CAS No.
86847-84-9
Chemical Name
N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
Synonyms
N-(6-chloropyridin-2-yl)pivalamide;N-(6-chloropyridin-2-yl)-2,2-dimethylpropanamide;N-(6-chloro-2-pyridinyl)-2,2-dimethylpropanamide;Propanamide, N-(6-chloro-2-pyridinyl)-2,2-dimethyl-;N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE;N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE ISO 9001：2015 REACH
CBNumber
CB3456211
Molecular Formula
C10H13ClN2O
Formula Weight
212.68
MOL File
86847-84-9.mol
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N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE Property

Melting point:
86-87 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:
375.4±27.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
13.15±0.70(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000326
Product name
N-(6-Chloro-pyridin-2-yl)-2,2-dimethyl-propionamide
Purity
Aldrich
Packaging
1g
Price
$216
Updated
2025/07/31
TRC
Product number
C351040
Product name
N-(6-Chloro-pyridin-2-yl)-2,2-dimethyl-propionamide
Packaging
250mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC139893
Product name
N-(6-Chloropyridin-2-yl)pivalamide
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC139893
Product name
N-(6-Chloropyridin-2-yl)pivalamide
Packaging
1g
Price
$111
Updated
2021/12/16
Matrix Scientific
Product number
026142
Product name
N-(6-Chloro-pyridin-2-yl)-2,2-dimethyl-propionamide
Packaging
500mg
Price
$161
Updated
2021/12/16
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N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE Chemical Properties,Usage,Production

Synthesis

45644-21-1

3282-30-2

86847-84-9

An anhydrous dichloromethane solution of valeroyl chloride (0.32 mL, 2.57 mmol) was slowly added dropwise to an anhydrous dichloromethane suspension of 2-amino-6-chloropyridine (0.30 g, 2.33 mmol) and triethylamine (0.41 mL, 2.92 mmol) at 0 °C. The reaction mixture was kept stirred at 0 °C for 50 min, followed by gradual warming to room temperature to continue the reaction. After 5 hours of reaction, the mixture was poured into water and the organic phase was separated. The aqueous layer was extracted with dichloromethane and the combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by Combiflash fast chromatography system using 0-15% ethyl acetate/hexane gradient elution to afford N-(6-chloropyridin-2-yl)-2,2-dimethylpropionamide (0.48 g, 2.28 mmol, 98% yield) as a white solid.

References

[1] Patent: WO2011/50245, 2011, A1. Location in patent: Page/Page column 118
[2] Patent: WO2008/128942, 2008, A1. Location in patent: Page/Page column 33
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3134 - 3147
[4] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 92
[5] Organic Process Research and Development, 2009, vol. 13, # 3, p. 555 - 566

N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE Suppliers

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View Lastest Price from N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE manufacturers

Dideu Industries Group Limited
Product
N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE 86847-84-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03

86847-84-9, N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDERelated Search:

N-(6-CHLORO-2-PYRIDINYL)-ACETAMIDE N-(6-METHOXY-PYRIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE N,N-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine N-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine 4-Acetamido-3-(trifluoromethy)phenylboronic acid, 4-(N-PHENYLAMINOMETHYL)PHENYLBORONIC ACID 4-(2-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PHENOXY]-ETHYL)-MORPHOLINE N-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)acetamide 3-(Diethylcarbamoyl)-2-fluorophenylboronic acid,pinacol ester N-(3-DIMETHYLAMINOPROPYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZAMIDE N-(6-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-naphthalen-2-yl)MethanesulfonaMide N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide N-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-1-amine N-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide 3-(N,N-DIMETHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER 3-(2-Methoxyethylaminocarbonyl)benzeneboronic acid pinacol ester 3-(4-FLUOROPHENYL)AMINOCARBONYLPHENYLBORONIC ACID PINACOL ESTER

  • N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
  • N-(6-chloropyridin-2-yl)-2,2-dimethylpropanamide
  • N-(6-chloropyridin-2-yl)pivalamide
  • N-(6-chloro-2-pyridinyl)-2,2-dimethylpropanamide
  • Propanamide, N-(6-chloro-2-pyridinyl)-2,2-dimethyl-
  • N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE ISO 9001：2015 REACH
  • 86847-84-9