Uses
ChemicalBook > CAS DataBase List > 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER

Uses
Product Name
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
CAS No.
680596-79-6
Chemical Name
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
Synonyms
4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane;1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL;1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER;1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester;1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER;(1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER;1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901;1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester;8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspi...;8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
CBNumber
CB3460797
Molecular Formula
C14H23BO4
Formula Weight
266.14
MOL File
680596-79-6.mol
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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Property

Melting point:
60-62°C
Boiling point:
313.9±52.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder to crystal
color 
White to Orange to Green
InChI
InChI=1S/C14H23BO4/c1-12(2)13(3,4)19-15(18-12)11-5-7-14(8-6-11)16-9-10-17-14/h5H,6-10H2,1-4H3
InChIKey
JCHWHOHZZYWUMP-UHFFFAOYSA-N
SMILES
O1C2(CCC(B3OC(C)(C)C(C)(C)O3)=CC2)OCC1
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
741671
Product name
1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$550
Updated
2023/06/20
Sigma-Aldrich
Product number
741671
Product name
1,4-Dioxaspiro[4.5]dec-7-en-8-boronic acid pinacol ester
Purity
97%
Packaging
500mg
Price
$390
Updated
2023/01/07
TCI Chemical
Product number
T3566
Product name
8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
Packaging
250MG
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
T3566
Product name
8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
Packaging
1G
Price
$116
Updated
2025/07/31
Usbiological
Product number
411359
Product name
1,4-Dioxa-spiro[4,5]dec-7-en-8-boronic acid, pinacol ester
Packaging
100mg
Price
$305
Updated
2021/12/16
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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Uses

1,4-Dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester is used as a pharmaceutical intermediate.

Synthesis

73183-34-3

170011-47-9

680596-79-6

1,4-Dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate (500 mg, 1.73 mmol) and pinacol bis(boronic acid) ester (530 mg, 2.08 mmol) were used as the raw materials, and 1,4-dioxane (8 mL) was used as the solvent under nitrogen protection, and potassium acetate (260 mg, 2.64 mmol) and Pd(dppf) Cl2 (130 mg, 0.17 mmol). The reaction mixture was stirred at 110 °C for 10 hours. After completion of the reaction, the insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure and purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v=2/1) to afford 540 mg of the yellow oily product 1,4-dioxa-spiro[4,5]dec-7-ene-8-boronic acid pinacol ester in 99% yield.

References

[1] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0431; 0432; 0433
[2] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 20
[3] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 102
[4] Patent: WO2017/192811, 2017, A1. Location in patent: Paragraph 00173
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5377 - 5380

1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Suppliers

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View Lastest Price from 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER 680596-79-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

680596-79-6, 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTERRelated Search:

Tetrahydrofuran E-HEXEN-1-YLBORONIC ACID BUTYLDIISOPROPOXYBORANE Isopropenylboronic acid pinacol ester 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER Cyclohexene-1-boronic acid pinacol ester HEXYLBORONIC ACID PINACOL ESTER 1-CYCLOHEXENYLBORONIC ACID n-Butylboronic acid TRANS-1-HEXENYLBORONIC ACID PINACOL ESTER E-2-(1-PENTENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 1-Hexaneboronic acid 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID 2-BUTYL-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

  • 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER
  • 4,4,5,5-Tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane
  • 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 3-hydroxy-2,3-diMethylbutan-2-yl hydrogen 1,4-dioxaspiro[4.5]dec-7-en-8-ylboronate
  • 2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
  • 2-(1,4-Dioxaspiro[4.5]dec-8-en-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1,4-Dioxaspiro[4,5]dec-7-en-8-boronic acid pinacol ester 0901
  • 1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PICOL ESTER
  • 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-7-ene
  • (1,4-DIOXASPIRO[4.5]DEC-7-EN-8-YL)BORONIC ACID PINACOL ESTER
  • 1,4-Dioxaspiro[4.5]-7-decene-8-boronic Acid Pinacol Ester
  • 1,4-Dioxa-Spiro[4,5]Dec-7-En-8-Boronic Acid PinacoL
  • 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspi...
  • 1,4- dioxo spiro [4,5] decan -7- ene -8- borate pinacol ester
  • 2-{1,4-dioxaspiro[4.5]dec-7-en-8-yl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D24870]
  • 680596-79-6
  • C14H23BO4
  • Organic boronic acid
  • blocks
  • BoronicAcids